Plasmid DNA vaccination
Plasmid DNA vaccination
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DOI：
10.1016/j.micinf.2005.03.010
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发表时间：
2005-05-01
影响因子：
5.8
通讯作者：
Huygen, K
中科院分区：
文献类型：
--
作者：
Huygen, K
结核病质粒DNA疫苗是一种非常有效和简单的方法，可诱导小鼠产生强烈的体液应答、CD 4+介导的Th 1细胞因子分泌和CD 8+介导的CTL活性。迄今为止，结核病DNA疫苗尚未在人类中进行评估，DNA的临床试验总体上有些令人失望。然而，许多研究报道了质粒DNA对Th 1和CD 8+介导的免疫应答的有效引发能力，其随后可以通过重组蛋白或重组痘病毒加强。关于结核病，用牛分枝杆菌BCG疫苗的初免/加强方案特别有希望，值得进一步分析。(c)2005年，Elsevier SAS。All rights reserved.
Plasmid DNA vaccination against tuberculosis is a very powerful and easy method for the induction of strong humoral responses, CD4+ mediated secretion of Th1 cytokines and CD8+ mediated CTL activity in mice. Tuberculosis DNA vaccines have not been assessed so far in humans, and clinical trials with DNA in general have been somewhat disappointing. However, numerous studies have reported on the potent priming capacity of plasmid DNA for Th1 and CD8+ mediated immune responses, which can be boosted subsequently by recombinant protein or recombinant pox-viruses. With respect to tuberculosis, prime/boost regimens with Mycobacterium bovis BCG vaccine are particularly promising and warrant further analysis. (c) 2005 Elsevier SAS. All rights reserved.