Carotid and aortic baroreceptor control of heart rate in conscious monkey.
Carotid and aortic baroreceptor control of heart rate in conscious monkey.
复制标题
颈动脉和主动脉压力感受器对清醒猴子心率的控制。
DOI：
10.1152/ajpheart.1987.253.4.h811
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Cornish,KG
中科院分区：
文献类型：
--
作者：
Barazanji,MW;Cornish,KG
这项研究观察了笼子和实验室中的主动脉和颈动脉压力感受器在控制清醒猴子心率方面的差异。猕猴和放射猴接受压力感受器去神经的顺序，首先剥离主动脉弓，然后剥离一个颈动脉窦，最后第二个颈动脉窦[去窦弓神经(SAD)]。四只猴子在去神经支配主动脉弓之前去神经支配颈动脉窦。用硝普钠和盐酸苯肾上腺素测定平均动脉压(MABP)-心率(HR)曲线。除SAD动物外，实验室内所有动物(对照组和失神经支配组)的峰值敏感度(PS)均显著低于笼养动物(P<0.05)，差异无统计学意义。笼子内对照动物和去主动脉神经动物的敏感度没有显著差异。去主动脉弓和一侧颈动脉窦后，PS明显降低。只有主动脉压力感受器完好无损的猴子的压力感受器反射曲线与SAD动物相似。完全性SAD后，PS基本为零。我们的结论是：1)笼养猕猴的MABP-HR反射的最大斜率比在实验室时大，这可能是由于交感神经张力的增加；2)清醒猴的颈动脉压力感受器对压力反射的HR成分的影响比主动脉压力感受器的影响更大。
This study looks at the difference between the aortic and the carotid baroreceptors in controlling the heart rate of conscious monkeys in the cage vs. the laboratory. Macaca mulatta and M. radiata underwent sequential baroreceptor denervation by first stripping the aortic arch, then one carotid sinus, and finally the second carotid sinus [sinoaortic denervation (SAD)]. Four monkeys had the carotid sinuses denervated before denervation of the aortic arch. Mean arterial blood pressure (MABP)-heart rate (HR) curves were determined by infusing nitroprusside and phenylephrine hydrochloride. The peak sensitivity (PS) was significantly less for all animals (control and denervated) in the laboratory than in the cage (P less than 0.05) with the exception of the SAD animals, which showed no difference. There was no significant difference in sensitivity between control and aortic-denervated animals in the cage. The PS decreased significantly after denervation of aortic arch and one carotid sinus. Monkeys with only the aortic baroreceptors intact had gains for the baroreflex curves that were similar to that of the SAD animals. After complete SAD the PS were essentially zero. We concluded that 1) the maximum slope of the MABP-HR reflex is greater when the monkey is in the cage than it is in the laboratory, probably resulting from an increase in the sympathetic tone; and 2) the carotid baroreceptors exert a greater influence on the HR component of the baroreflex in the conscious monkey than do the aortic baroreceptors.