AMPK as a New Attractive Therapeutic Target for Disease Prevention: The Role of Dietary Compounds AMPK and Disease Prevention
AMPK as a New Attractive Therapeutic Target for Disease Prevention: The Role of Dietary Compounds AMPK and Disease Prevention
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DOI：
10.2174/1573399811666150615150235
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发表时间：
2016-01-01
影响因子：
3.2
通讯作者：
Battino, Maurizio
中科院分区：
文献类型：
--
作者：
Gasparrini, Massimiliano;Giampieri, Francesca;Battino, Maurizio
AMPK是一种丝氨酸/苏氨酸蛋白激酶，在大多数真核细胞中具有维持ATP产生和消耗之间平衡的功能。它在调节细胞代谢、维持细胞能量稳态中起相关作用，并且参与许多其他细胞过程以及代谢过程，包括细胞周期调节以及内皮和血管舒张。近年来，天然存在的化合物能够通过AMPK激活来预防和治疗疾病的作用引起了许多研究人员的注意。在这些化合物中，在天然来源中发现的类黄酮，如槲皮素、染料木黄酮、表没食子儿茶素、白藜芦醇，已被提议作为AMPK激活剂。本文综述了近年来植物性食物中不同膳食化合物对AMPK通路的影响机制，特别是对糖尿病、肥胖、代谢综合征、心血管疾病和癌症的分子机制的研究进展。
AMPK is a serine/threonine protein kinase that has the function of maintaining the balance between ATP production and consumption in most eukaryotic cells. It plays a relevant role in regulating cellular metabolism, preserving cellular energy homeostasis, and is involved in many other cellular processes as well as metabolic ones, including cell cycle regulation and endothelial and vascular relaxation. Recently, the effects of naturally occurring compounds able to prevent and treat diseases through AMPK activation have attracted the attention of many researchers. Among such compounds, flavonoids found in natural sources, like quercetin, genistein, epigallocatechins, resveratrol, have been proposed as AMPK activators. This review summarizes and updates the most recent findings concerning the mechanisms through which different dietary compounds, from plant foods, affect the AMPK pathway in healthy and pathological in vitro and in vivo models, paying particular attention to molecular mechanisms involved in diabetes, obesity, metabolic syndrome, cardiovascular disease and cancer.