Progress of malignant mesothelioma research in basic science: A review of the 14th international conference of the international mesothelioma interest group (iMig2018).
Progress of malignant mesothelioma research in basic science: A review of the 14th international conference of the international mesothelioma interest group (iMig2018).
复制标题
DOI：
10.1016/j.lungcan.2018.11.034
复制
发表时间：
2019-01
期刊：
影响因子：
5.3
通讯作者：
Licun Wu;I. Dell'Anno;M. Lapidot;Y. Sekido;M. Chan;M. Kohno;V. Serre-Beinier;E. Felley-Bosco;M. de Perrot
中科院分区：
文献类型：
--
作者：
Licun Wu;I. Dell'Anno;M. Lapidot;Y. Sekido;M. Chan;M. Kohno;V. Serre-Beinier;E. Felley-Bosco;M. de Perrot
在这里，我们总结了在14 thiMig 2018国际会议上提出的基础科学间皮瘤研究的最新更新。基础科学轨道的研讨会主要集中在间皮瘤开始和进展的驱动因素，分子发病机制，以及对潜在的治疗方法的观点。本文综述了几个有前途的领域，包括有效抑制雅普/TAZ功能或其关键下游靶点的策略，乙酰肝素酶抑制剂，RAN耗竭，和MIF/CD 74抑制剂，可能会被开发为新的治疗方法。此外，通过耗尽肿瘤微环境中的M2极化巨噬细胞或阻断Tnfsf 18（GITRL）-GITR信号传导来靶向间皮瘤干细胞，可能会转化为间皮瘤治疗的治疗方式。
Here we summarize the most recent update of mesothelioma research in basic science presented at the 14thiMig2018 international conference. The symposium of basic science track mainly focused on the drivers of mesothelioma initiation and progression, molecular pathogenesis, and perspectives on potential therapeutic approaches. This review covers several promising fields including strategies efficiently inhibiting YAP/TAZ functions or their critical downstream targets, heparanase inhibitors,RANdepletion, and MIF/CD74 inhibitors that may be developed as novel therapeutic approaches. In addition, targeting mesothelioma stem cells by depleting M2-polarized macrophages in tumor microenvironment or blocking Tnfsf18 (GITRL)-GITR signalling might be translated into therapeutic modalities in mesothelioma treatment.