Bif‐1 and Bax expression in cutaneous Merkel cell carcinoma
Bif‐1 and Bax expression in cutaneous Merkel cell carcinoma
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DOI：
10.1111/j.1600-0560.2007.00945.x
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发表时间：
2009-01
影响因子：
1.7
通讯作者：
Scott M. Schlauder;K. Calder;F. Khalil;Leslie M Passmore;Rahel A Mathew;M. Morgan
中科院分区：
文献类型：
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作者：
Scott M. Schlauder;K. Calder;F. Khalil;Leslie M Passmore;Rahel A Mathew;M. Morgan
背景：Bax相互作用因子-1（Bif-1）与Bax结合，进而激活这种促凋亡蛋白。在缺乏Bif-1的情况下，通过内在途径诱导细胞凋亡的能力大大降低。默克尔细胞癌（MCC）典型地表现出攻击性行为和对化疗缺乏反应，这仍然无法解释。以前的研究已经记录了MCC中Bax的存在，但尚未评估Bif‐1的表达。在此，检查皮肤MCC中Bif-1和Bax的表达。
Background: Bax‐interacting factor‐1 (Bif‐1) binds to Bax, which in turn activates this proapoptotic protein. In the absence of Bif‐1, the ability to induce apoptosis through the intrinsic pathway is greatly reduced. Merkel cell carcinoma (MCC) classically shows an aggressive behavior and lack of response to chemotherapy, which remains unexplained. Previous studies have documented the presence of Bax in MCC, but Bif‐1 expression has not been evaluated. Herein, the expression of Bif‐1 and Bax in cutaneous MCC is examined.