Abdominal vagus and regulation of ingestive behavior and body weight in golden hamsters.
Abdominal vagus and regulation of ingestive behavior and body weight in golden hamsters.
复制标题
金仓鼠的腹部迷走神经以及摄入行为和体重的调节。
DOI：
10.1152/ajpregu.1985.248.6.r686
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Miceli,MO
中科院分区：
文献类型：
--
作者：
Miceli,MO
本研究以叙利亚仓鼠为实验动物，研究了迷走神经在体重调节和摄食行为控制中的作用。本研究以全胃下迷走神经切断术或选择性胃迷走神经切断术的仓鼠为实验动物，观察其体重、摄食量、饮水量及对胆囊收缩素（CCK）的摄食反应。在自由采食期间，体重和摄食量不受任一类型迷走神经切断术的影响。然而，在间歇性食物获取期间，全延髓下或胃迷走神经切断的仓鼠可以更好地维持体重。迷走神经切断术阻断低剂量（4.0微克/千克）CCK八肽（CCK-8）全身注射后的摄食抑制。这种阻断作用是特定的喂养抑制CCK-8的反应，因为迷走神经切断仓鼠仍然对其他假定的饱腹激素（蛙皮素，降钙素和促甲状腺激素释放激素）。然而，任一种迷走神经切断术的仓鼠对高剂量（大于或等于8.0 μ g/kg）CCK-8有反应，因此表明CCK作用的外（可能是中枢神经系统）部位也可能与摄食控制有关。结果进行了讨论，在正常的迷走神经功能的仓鼠和迷走神经控制的摄食行为在其他物种。
A series of experiments was undertaken to examine the role of the vagus nerve in body weight regulation and the control of ingestive behavior in Syrian hamsters. Body weight, food and water intake, and feeding responsiveness to the putative satiety hormone cholecystokinin (CCK) were studied in hamsters with total subdiaphragmatic or selective gastric vagotomy. Body weight and food intake during ad libitum feeding were unaffected by either type of vagotomy. However, hamsters with total subdiaphragmatic or gastric vagotomy could better maintain body weight during intermittent food access. Vagotomy blocked feeding suppression after low-dose (4.0 micrograms/kg) systemic injections of CCK octapeptide (CCK-8). This blocking effect was specific to feeding suppression in response to CCK-8, because vagotomized hamsters remained responsive to other putative satiety hormones (bombesin, calcitonin, and thyrotropin-releasing hormone). Hamsters with either type of vagotomy were, however, responsive to high doses (greater than or equal to 8.0 micrograms/kg) of CCK-8, thus indicating that extravagal (possibly central nervous system) sites of CCK action may also be relevant to the control of feeding. The results are discussed in relation to normal vagal function in hamsters and vagal control of ingestive behavior in other species.