Visuospatial dysfunction and problem solving in Parkinson's disease
Visuospatial dysfunction and problem solving in Parkinson's disease
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DOI：
10.1037/0894-4105.11.1.44
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发表时间：
1997-01-01
期刊：
影响因子：
2.4
通讯作者：
Braun, AE
中科院分区：
文献类型：
--
作者：
CroninGolomb, A;Braun, AE
帕金森氏症患者在乌鸦有色递进矩阵(RCPM)上表现不佳，与他们在许多其他问题服务任务上相对较好的表现形成鲜明对比。提出了一个问题，即视觉空间缺陷是否可能是帕金森病患者RCPM表现不佳的原因。作者分析了50名患有帕金森病的非痴呆参与者和39名年龄匹配的健康对照组参与者的RCPM结果。帕金森病组在所有RCPM分测验，包括主要评估视觉空间功能的分测验(RCPM-A)上犯的错误明显多于对照组。对于PD组，其他视觉空间测试的综合分数，而不是执行功能或言语记忆测试的综合分数，显著预测了RCPM-A的表现。帕金森病患者的视觉空间障碍可能源于基底节-丘脑皮质环路的功能障碍，该环路还包括背外侧前额叶，更重要的是，顶叶后叶。
Individuals with Parkinson's disease (PD) perform deficiently on Raven's Coloured Progressive Matrices (RCPM), in contrast to their relatively good performance on many other problem-serving tasks. The question is raised as to whether a visuospatial deficit may account for poor RCPM performance in PD. The authors analyzed RCPM results in 50 nondemented participants with PD and 39 age-matched healthy control participants. The PD group made significantly more errors than the control group on all RCPM subtests, including the subtest that mainly assessed visuospatial function (RCPM-A). For the PD group, the composite score of other visuospatial tests, but not the composite scores of tests of executive function or verbal memory, significantly predicted performance on the RCPM-A. Visuospatial impairment in PD may arise from dysfunction of the basal ganglia-thalamocortical circuit that also includes the dorsolateral prefrontal cortex and, importantly, the posterior parietal lobes.