Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study - A large observational study of the determinants of fracture in older men
Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study - A large observational study of the determinants of fracture in older men
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DOI：
10.1016/j.cct.2005.05.006
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发表时间：
2005-10-01
影响因子：
2.2
通讯作者：
Stone, K
中科院分区：
文献类型：
--
作者：
Orwoll, E;Blank, JB;Stone, K
很少有信息可用于指导男性骨质疏松症的预防或管理。男性骨质疏松性骨折（MrOS）研究是一项前瞻性队列研究，旨在检查骨折风险与骨量、骨几何结构、生活方式、人体测量和神经肌肉测量以及跌倒倾向的相关程度，并确定骨折如何影响男性的生活质量。这项研究还旨在了解骨质疏松症与前列腺疾病的关系。在基线时，参与者完成了关于病史、药物、体力活动、饮食、饮酒和吸烟的问卷调查。获得了人体测量、神经肌肉、视力、力量和认知变量的客观测量结果。骨骼评估包括DEXA、跟骨超声和椎骨X线片。对一个子集（65%）进行了椎体和股骨近端QCT。收集血清、尿液和DNA标本。在基线评估后，每4个月向参与者邮寄一份问卷，以确定事件福尔斯、骨折、前列腺癌和死亡。平均4.5年后，参与者计划再次进行全面访问。如果年龄≥ 65岁，则符合条件。5995名男性入组，平均（+/- SD）年龄为73.7（+/- 5.9）岁，其中11%为少数民族。大多数人认为他们的健康状况良好/非常好。目前很少有人吸烟，尽管59%的人以前吸烟，35%的人报告没有饮酒，而47%的人每周至少喝2杯。平均（范围）体重指数为26.9 kg/m2（17-56）。50岁以后有17%的人报告了非创伤性骨折，MrOS队列应该提供关于男性骨折决定因素的有价值的信息，并应该帮助制定有效的方法来识别风险人群。(c)2005年爱思唯尔公司All rights reserved.
Very little information is available to direct the prevention or management of osteoporosis in men. The Osteoporotic Fractures in Men (MrOS) Study is a prospective cohort study designed to examine the extent to which fracture risk is related to bone mass, bone geometry, lifestyle, anthropometric and neuromuscular measures, and fall propensity, as well as to determine how fractures affect quality of life in men. The study is also designed to understand how osteoporosis is related to prostate disease.At baseline, participants completed questionnaires regarding medical history, medications, physical activity, diet, alcohol intake, and cigarette smoking. Objective measures of anthropometric, neuromuscular, vision, strength, and cognitive variables were obtained. Skeletal assessments included DEXA, calcaneal ultrasound, and vertebral radiographs. Vertebral and proximal femoral QCT was performed on a subset (65%). Serum, urine, and DNA specimens were collected. After the baseline assessments, a questionnaire is mailed to participants every 4 months to ascertain incident falls, fractures, prostate cancer, and deaths. After an average of 4.5 years, participants are scheduled to return for a second comprehensive visit.Men were eligible if >= 65 years. 5995 men enrolled with a mean (+/- SD) age of 73.7 (+/- 5.9) years, 11% of which were minorities. Most rated their health as good/excellent. Few were current smokers, although 59% had smoked previously, and 35% reported no alcohol intake, while 47% consumed at least 2 drinks per week. The mean (range) body mass index was 26.9 kg/m(2) (17-56). A non-traumatic fracture after age 50 was reported by 17% of the cohort.The MrOS cohort should provide valuable information concerning the determinants of fracture in men and should help set the stage for the development of effective methods to identify those at risk. (c) 2005 Elsevier Inc. All rights reserved.