Measuring Tablet Dissolution: An Experiment for Teaching Quantitative Ultraviolet Absorption Spectroscopy
Measuring Tablet Dissolution: An Experiment for Teaching Quantitative Ultraviolet Absorption Spectroscopy
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测量片剂溶出度：定量紫外吸收光谱法教学实验
DOI：
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Mazen L. Hamad
中科院分区：
文献类型：
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作者：
Mazen L. Hamad
溶出度试验是一种定量分析技术，用于测定片剂和胶囊中成分的释放速度。这个仪器分析实验室实验教学生如何从粉末混合物中压缩片剂，并挑战学生建立自己的仪器来测量片剂的溶出率。每组学生都能够成功地完成实验，并阐明了五组药片的溶出率的两个预测趋势。学生们学习了紫外光谱、数据处理、校准和采样的基础知识，同时获得了关于制药和膳食补充剂行业中使用的重要测试的见解和经验。
Dissolution testing is a quantitative analytical technique used to measure the release rate of ingredients from tablets and capsules. This instrumental analysis lab experiment teaches students how to compress tablets from a mixture of powders and challenges students to build their own apparatus to measure dissolution rates of their tablets. Each group of students was able to complete the experiment successfully and elucidate two predicted trends in dissolution rates from a set of five tablets. Students learned the fundamentals of UV spectroscopy, data handling, calibration, and sampling, while gaining insight and experience regarding an important test used in the pharmaceutical and dietary supplement industries.