Crisaborole ointment as treatment for genital psoriasis
Crisaborole ointment as treatment for genital psoriasis
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Crisaborole 软膏治疗生殖器牛皮癣
DOI：
10.1111/jocd.14706
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发表时间：
2021-12
影响因子：
2.3
通讯作者：
Wei Li
中科院分区：
文献类型：
--
作者：
Yiyuan Liu;Wei Li
根据编辑的说法，三分之一以上的牛皮癣患者会患上生殖器牛皮癣。1生殖器牛皮癣的治疗具有挑战性，因为生殖器皮肤很薄，而且对某些疗法敏感。局部治疗，包括皮质类固醇(TCS)和局部钙调神经磷酸酶抑制剂(TCI)，是治疗生殖器银屑病的首选药物。2然而，由于疗效、耐受性和副作用的局限性，TCS和TCI不能改善生殖器银屑病。Crisborole是一种新型的非类固醇磷酸二酯酶4(PDE4)抑制剂，于2016年被批准用于治疗儿童和成人中中度特应性皮炎(AD)。3 Crisborole增加细胞内环磷酸腺苷的水平，它减少促炎细胞因子的产生，包括Th1型细胞因子(肿瘤坏死因子α、干扰素γ)、Th2型细胞因子(IL4、IL13)和IL17.4在此，我们报告了外用Crisborole成功治疗生殖器银屑病的病例系列。
To the Editor, Genital psoriasis develops in more than onethird of patients who have psoriasis.1 The treatment of genital psoriasis is challenging because the genital skin is thin and sensitive to some therapies. Topical treatments, including corticosteroids (TCS) and topical calcineurin inhibitors (TCI), are the firstline recommendation of treating genital psoriasis.2 However, TCS and TCI could not improve genital psoriasis for their limitations of efficacy, tolerability, and side effects. Crisaborole, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor, is approved in 2016 as the topical treatment of mildmoderate atopic dermatitis (AD) in children and adults.3 Crisaborole increases levels of intracellular cyclic adenosine monophosphate, which decreases the production of proinflammatory cytokines, including Th1 cytokines (TNFα, interferonγ), Th2 cytokines (IL4, Il13), and IL17.4 Here, we report case series of genital psoriasis successfully treated with topical crisaborole.
影响因子：
14.2
作者：
Bissonnette, Robert;Pavel, Ana B.;Guttman-Yassky, Emma
通讯作者：
Guttman-Yassky, Emma
影响因子：
3.4
作者：
Hong JJ;Mosca ML;Hadeler EK;Brownstone ND;Bhutani T;Liao WJ
通讯作者：
Liao WJ
影响因子：
13.8
作者：
Paller, Amy S.;Tom, Wynnis L.;Hebert, Adelaide A.
通讯作者：
Hebert, Adelaide A.