CLINICAL AND EPIDEMIOLOGIC ASPECTS OF ALZHEIMERS-DISEASE WITH PRESENILE ONSET - A CASE CONTROL STUDY
CLINICAL AND EPIDEMIOLOGIC ASPECTS OF ALZHEIMERS-DISEASE WITH PRESENILE ONSET - A CASE CONTROL STUDY
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DOI：
10.1159/000110750
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发表时间：
1990-01-01
影响因子：
5.7
通讯作者：
FRANCESCHI, M
中科院分区：
文献类型：
--
作者：
FERINISTRAMBI, L;SMIRNE, S;FRANCESCHI, M
关于阿尔茨海默病的致病因素我们知之甚少。我们研究了63名AD患者，以评估AD是否有临床亚型，以及既往疾病和生活方式是否与疾病的发生有关。在我们选择的65岁之前出现症状的患者中，我们没有发现任何显著的临床异质性。此外，我们没有发现任何可以预测老年前期AD发展的病史数据，但观察到AD患者家族中痴呆的发生率显著高于对照组。
Little is known regarding the pathogenetic factors for Alzheimer''s disease (AD). We studied 63 AD patients in order to evaluate if there were clinical subtypes of AD and whether prior illnesses and life-styles were involved in the development of the disease. In our patients selected for onset of symptoms before age 65 we did not find any significant clinical heterogeneity. Furthermore, we found no data in the medical history that are predictive for the development of presenile AD but observed a significantly increased frequency of dementia in the families of AD patients in comparison to controls.