Respiratory effects of relocating to areas of differing air pollution levels
Respiratory effects of relocating to areas of differing air pollution levels
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DOI：
10.1164/ajrccm.164.11.2102005
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发表时间：
2001-12-01
影响因子：
24.7
通讯作者：
Peters, JM
中科院分区：
文献类型：
--
作者：
Avol, EL;Gauderman, WJ;Peters, JM
我们研究了110名儿童（59名男孩和51名女孩，入组时年龄为10岁，随访时年龄为15岁），这些儿童从参与10年呼吸健康前瞻性研究（儿童健康研究[CHS]）的社区搬迁，以确定搬迁引起的空气质量变化是否与年度肺功能增长率的变化相关。根据与每年在学校对CHS队列进行的评估相同的协议，受试者在西部六个州的家中接受了健康问卷调查和肺量测定。年平均暴露于平均直径为10 μ m的颗粒物（PM10）的变化与FEV 1、最大呼气中期流量和峰值呼气流速的年肺功能增长率差异相关。作为一个群体，搬到PM10较低地区的受试者肺功能增长增加，搬到PM10较高社区的受试者肺功能增长下降。在随访访视前至少3年迁移的受试者比在前1 - 2年迁移的受试者有更强的趋势。我们的结论是，在青少年成长期间的空气污染暴露的变化有一个可测量的和潜在的重要影响肺功能的增长和性能。
We studied 110 children (59 boys and 51 girls, who were 10 yr of age at enrollment and 15 yr of age at follow-up) who had moved from communities participating in a 10-yr prospective study of respiratory health (The Children's Health Study [CHS]) to determine whether changes in air quality caused by relocation were associated with changes in annual lung function growth rates. The subjects were given health questionnaires and underwent spirometry in their homes across six western states, according to a protocol identical to evaluations performed annually on the CHS cohort in school. Changes in annual average exposure to particulate matter with a mean diameter of 10 mum (PM10) were associated with differences in annual lung function growth rates for FEV1, maximal mid-expiratory flow, and peak expiratory flow rate. As a group, subjects who had moved to areas of lower PM10 showed increased growth in lung function and subjects who moved to communities with a higher PM10 showed decreased growth in lung function. A stronger trend was found for subjects who had migrated at least 3 yr before the follow-up visit than for those who had moved in the previous 1 to 2 yr. We conclude that changes in air pollution exposure during adolescent growth years have a measurable and potentially important effect on lung function growth and performance.