Continuous microinstillation of phenol red on liver surface for liver site-selective delivery.
Continuous microinstillation of phenol red on liver surface for liver site-selective delivery.
复制标题
在肝脏表面连续微量滴注酚红以进行肝脏部位选择性递送。
DOI：
10.1248/bpb.22.713
复制
发表时间：
1999
影响因子：
2
通讯作者：
H. Sasaki
中科院分区：
文献类型：
--
作者：
J. Nakamura;Y. Yoshida;K. Mera;T. Mukai;K. Nishida;H. Sasaki
我们报告了一种非常有前途的方法，通过在肝脏表面滴注药物来进行肝脏位点选择性药物输送。选取酚红作为模型药物，滴注于大鼠肝脏表面后在滴注部位积累。通过在肝脏表面逐渐持续滴注少量药物溶液来增强位点选择性定位。
We report a very promising approach for liver site-selective drug delivery through drug instillation on liver surface. Phenol red, which was selected as a model drug, was accumulated in the instillation site after instillation on the rat liver surface. The site-selective localization was enhanced by gradually and continuously instilling a small amount of drug solution on the liver surface.