Excess mortality in severe mental illness: 10-year population-based cohort study in rural Ethiopia
Excess mortality in severe mental illness: 10-year population-based cohort study in rural Ethiopia
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DOI：
10.1192/bjp.bp.114.149112
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发表时间：
2015-04-01
影响因子：
10.5
通讯作者：
Shibre, Teshome
中科院分区：
文献类型：
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作者：
Fekadu, Abebaw;Medhin, Girmay;Shibre, Teshome
背景关于严重精神疾病 (SMI) 死亡率的证据主要来自高收入国家的临床样本。目的是描述低收入国家人群中 SMI 患者的死亡率。方法我们对 919 名患有 SMI 的成年人（来自 68 378 名筛查者）进行了 10 年的随访。计算标准化死亡率（SMR）和过早死亡导致的生命损失年数（YLL）。结果共有121名患者（13.2%）死亡。总体 SMR 是普通人群的两倍；男性和精神分裂症患者的比例更高。患者大约提前三十岁死亡，主要死于感染原因（49.6%）。自杀、事故和他杀也是常见的死亡原因。 结论 无论背景如何，死亡率都是 SMI 的一个重要不良结局。解决常见的自然和非自然死亡原因是当务之急。在估计全球 SMI 疾病负担时，应考虑过早死亡和与自残相关的死亡率。
BackgroundEvidence on mortality in severe mental illness (SMI) comes primarily from clinical samples in high-income countries.AimsTo describe mortality in people with SMI among a population cohort from a low-income country.MethodWe followed-up 919 adults (from 68 378 screened) with SMI over 10 years. Standardised mortality ratios (SMR) and years of life lost (YLL) as a result of premature mortality were calculated.ResultsIn total 121 patients (13.2%) died. The overall SMR was twice that of the general population; higher for men and people With schizophrenia. Patients died about three decades prematurely, mainly from infectious causes (49.6%). Suicide, accidents and homicide were also common causes of death.ConclusionsMortality is an important adverse outcome of SMI irrespective of setting. Addressing common natural and unnatural causes of mortality are urgent priorities. Premature death and mortality related to self-harm should be considered in the estimation of the global burden of disease for SMI.