The relationship between chronic atrial fibrillation and reduced pulmonary function in cases of preserved left ventricular systolic function.
The relationship between chronic atrial fibrillation and reduced pulmonary function in cases of preserved left ventricular systolic function.
复制标题
DOI：
10.4070/kcj.2009.39.9.372
复制
发表时间：
2009-09
影响因子：
2.9
通讯作者：
Jung BC
中科院分区：
文献类型：
--
作者：
Kang H;Bae BS;Kim JH;Jang HS;Lee BR;Jung BC
本研究旨在探讨慢性心房颤动（AF）与肺功能下降的关系。86例慢性房颤患者从每年的健康检查计划中招募，使用超声心动图和肺功能测试（PFT）进行了研究。年龄、性别和实施年份匹配的超声心动图和PFT由窦性心律正常的对照组选择。排除射血分数<50%、瓣膜性心脏病或缺血性心脏病患者。慢性房颤患者第1秒用力呼气容积（FEV 1）、FEV1%、FEV 1/用力肺活量（FVC）均显著降低，右室收缩压显著升高。慢性房颤患者较对照组更易发生心力衰竭。特别是，在调整心血管风险因素后，FEV1%与慢性AF的关系最有意义{p=0.003，Exp（B）=0.978，95%置信区间（CI）：0.963-0.993}。FEV1%降低（代表气道阻塞的严重程度）与慢性AF相关，在左心室收缩功能保留的患者中，肺功能损害越大，AF和充血性心力衰竭并存的程度越大。
The purpose of this study was to investigate the relationship between chronic atrial fibrillation (AF) and reduced pulmonary function. Eighty-six chronic AF patients who were enrolled from annual health examination programs were studied using echocardiography and pulmonary function tests (PFT). Echocardiography and PFT matched for age, gender, and year performed were selected by the control group who had normal sinus rhythms. Patients with ejection fractions <50%, valvular heart disease, or ischemic heart disease were excluded. In the chronic AF patients, the forced expiratory volume at one second (FEV1), FEV1%, and FEV1/forced vital capacity (FVC) were significantly reduced, and the right ventricular systolic pressure was significantly increased. Episodes of heart failure were more frequently associated with the chronic AF patients than the controls. In particular, the FEV1% had the most meaningful relationship to chronic AF after an adjustment for cardiovascular risk factors {p=0.003, Exp (B)=0.978, 95% confidence interval (CI):0.963-0.993}. Reduced FEV1%, which represents the severity of airway obstruction, was associated with chronic AF, and the greater the pulmonary function impairment, the greater the co-existence with AF and congestive heart failure in those with preserved left ventricular systolic function.