Detection and Characterization of Thrombosis in Humans Using Fibrin-Targeted Positron Emission Tomography and Magnetic Resonance.
Detection and Characterization of Thrombosis in Humans Using Fibrin-Targeted Positron Emission Tomography and Magnetic Resonance.
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DOI：
10.1016/j.jcmg.2021.08.009
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Sosnovik DE
中科院分区：
文献类型：
--
作者：
Izquierdo-Garcia D;Désogère P;Philip AL;Mekkaoui C;Weiner RB;Catalano OA;Iris Chen YC;DeFaria Yeh D;Mansour M;Catana C;Caravan P;Sosnovik DE
左心耳（LAA）血栓的检测对于预防卒中至关重要，目前使用经食管超声心动图（TEE）进行。我们提出了一种新的技术来检测和表征左心耳血栓在人类使用相结合的正电子发射断层扫描-磁共振成像（PET/MRI）的纤维蛋白结合放射性示踪剂，[64 Cu] FBP 8。研究了8名健康志愿者体内[64 Cu] FBP 8的代谢和药代动力学。对房颤（AF）和LAA近期TEE（阳性n=12，阴性n=12）患者注射[64 Cu] FBP 8并进行PET/MRI成像，包括绘制LAA中的纵向磁弛豫时间（T1）。[64 Cu] FBP 8对代谢稳定，并迅速消除。TEE阳性受试者的左心耳最大标准化摄取值（SUVMax）显著高于阴性受试者，中位数[四分位距]为4.0 [3.0-6.0] vs. 2.3 [2.1-2.5]; p < 0.001，受试者工作特征曲线下面积为0.97。2.6的SUVMax阈值提供了100%的灵敏度和84%的特异性。左心耳的最小T1（T1最小值）为970 ms [780-1080] vs. 1380 ms [1120-1620]（TEE阳性vs.阴性），p < 0.05，两组之间存在一些重叠。使用SUVMax和T1 Min的Logistic回归允许所有TEE阳性和阴性受试者以100%的准确率进行分类。[64 Cu] FBP 8的PET/MR能够以极好的准确性检测急性以及较老的贫血小板血栓。此外，集成PET/MRI方法提供了有关血栓生物学特性的有用信息，如纤维蛋白和高铁血红蛋白含量。左心耳血栓成像URL：https://clinicaltrials.gov/ct2/show/NCT03830320注册号：NCT 03830320
The detection of thrombus in the left atrial appendage (LAA) is vital in the prevention of stroke and is currently performed using transesophageal echocardiography (TEE). We present a novel technique to detect and characterize LAA thrombus in humans using combined positron emission tomography-magnetic resonance imaging (PET/MRI) of a fibrin-binding radiotracer, [64Cu]FBP8. The metabolism and pharmacokinetics of [64Cu]FBP8 were studied in 8 healthy volunteers. Patients with atrial fibrillation (AF) and recent TEEs of the LAA (positive n=12, negative n=12) were injected with [64Cu]FBP8 and imaged with PET/MRI, including mapping the longitudinal magnetic relaxation time (T1) in the LAA . [64Cu]FBP8 was stable to metabolism and was rapidly eliminated. The maximum standardized uptake value (SUVMax) in the LAA was significantly higher in the TEE positive than negative subjects, median [interquartile range] of 4.0 [3.0-6.0] vs. 2.3 [2.1-2.5]; p < 0.001, with an area-under-the-receiver operating characteristic curve of 0.97. A SUVMax threshold of 2.6 provided a sensitivity of 100% and specificity of 84%. The minimum T1 (T1Min) in the LAA was 970ms [780-1080] vs. 1380ms [1120-1620] (TEE positive vs. negative), p < 0.05, with some overlap between the groups. Logistic regression using SUVMax and T1Min allowed all TEE positive and negative subjects to be classified with 100% accuracy. PET/MR of [64Cu]FBP8 is able to detect acute as well as older platelet-poor thrombi with excellent accuracy. Furthermore, the integrated PET/MRI approach provides useful information on the biological properties of thrombus such as fibrin and methemoglobin content. Imaging of LAA Thrombosis URL: https://clinicaltrials.gov/ct2/show/NCT03830320 Registration number: NCT03830320
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影响因子：
4.7
作者：
Kolodziej, Andrew F.;Nair, Shrikumar A.;Graham, Philip;McMurry, Thomas J.;Ladner, Robert C.;Wescott, Charles;Sexton, Daniel J.;Caravan, Peter
通讯作者：
Caravan, Peter
影响因子：
39.2
作者：
MANNING, WJ;WEINTRAUB, RM;DOUGLAS, PS
通讯作者：
DOUGLAS, PS
DOI：
10.1007/s12350-017-0942-8
发表时间：
2019-06
期刊：
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
影响因子：
--
作者：
Lanza GM;Cui G;Schmieder AH;Zhang H;Allen JS;Scott MJ;Williams T;Yang X
通讯作者：
Yang X
影响因子：
8.3
作者：
WOLF, PA;ABBOTT, RD;KANNEL, WB
通讯作者：
KANNEL, WB
DOI：
10.1007/s00259-008-0934-7
发表时间：
2009-02-01
影响因子：
9.1
作者：
Macfarlane, David;Socrates, Angelides;Scott, Andrew M.
通讯作者：
Scott, Andrew M.