Distinctive homing profile of pathogen-specific activated lymphocytes in human urinary tract infection
Distinctive homing profile of pathogen-specific activated lymphocytes in human urinary tract infection
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DOI：
10.1016/j.clim.2008.05.003
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发表时间：
2008-09-01
影响因子：
8.6
通讯作者：
Kantele, Jussi M.
中科院分区：
文献类型：
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作者：
Kantele, Anu M.;Palkola, Nina V.;Kantele, Jussi M.
与其他粘膜部位相比，有关人类尿路中激活的淋巴细胞迁移/归巢的信息正在不断增加。淋巴细胞归巢受体（HR）的表达对病原体特异性抗体分泌细胞（ASC）从泌尿道（肾盂肾炎，PN患者）上的抗原特异性ASC从肠道（胃肠炎患者）或从肠胃外网站（破伤风类毒素免疫志愿者）进行了比较。在PN组中，61%的ASC表达肠道HR，α（4）β（7），52%表达外周淋巴结HR，L-选择素，13%表达皮肤HR，CLA。发现尿路来源淋巴细胞的这种归巢特征与两种主要疫苗接种途径不同，即肠道（肠道靶向较少）或胃肠外（肠道靶向较多，胃肠外部位靶向较少）。这一信息的免疫反应的目标可能证明是有用的，当开发针对尿路感染（UTI）的疫苗。(C)2008年爱思唯尔公司All rights reserved.
In contrast to other mucosal sites, information on migration/ homing of lymphocytes activated in the human urinary tract is tacking. The expression of lymphocyte homing receptors (HR) on pathogen-specific anti body-secreting cells (ASC) originating from the urinary tract (patients with pyelonephritis, PN) was compared to that on antigen-specific ASC originating from the intestine (patients with gastroenteritis) or from a parenteral site (tetanus toxoid-immunized volunteers). In the PN group, 61% of ASC expressed the gut HR, alpha(4)beta(7), 52% the peripheral lymph node HR, L-selectin, and 13% the skin HR, CLA. This homing profile of urinary tract-originating lymphocytes was found to differ from both of the two major vaccination routes, intestinal (less gut-targeting) or parenteral (more gut-targeting, less targeting to parenteral sites). This information on targeting of the immune response may prove useful when developing vaccines against urinary tract infection (UTI). (C) 2008 Elsevier Inc. All rights reserved.