Chromene-based Schiff Base Ligand: DNA Interaction Studies and Characterization of Tetranuclear Zinc, Nickel and Iron Complexes
Chromene-based Schiff Base Ligand: DNA Interaction Studies and Characterization of Tetranuclear Zinc, Nickel and Iron Complexes
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DOI：
10.1016/j.ica.2022.121363
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发表时间：
2022-12
影响因子：
2.8
通讯作者：
Andrew J. Ressler;Olivia N. Brandt;A. Weaver;Jenna E. Poor;Anna Ream;Nicolas A. Summers;C. McMillen;N. Seeram;W. Dougherty;G. Henry
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文献类型：
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作者：
Andrew J. Ressler;Olivia N. Brandt;A. Weaver;Jenna E. Poor;Anna Ream;Nicolas A. Summers;C. McMillen;N. Seeram;W. Dougherty;G. Henry
以2-氨基苯酚和5-hydroxy-2，2-dimethyl-2H-chromene-6-carbaldehyde.缩合而成的一种新的色烯类席夫碱配体(H_2L)为原料合成了三个四核簇合物：锌(II)、镍(II)和铁(III)通过单晶X-射线衍射和质谱分析确定了四核簇合物的结构。结晶学数据表明，锌和镍原子簇具有相似的结构[M4L4(THF)2]，并含有一个缺陷的双立方烷核心，每个配体通过三个施主原子与一个金属离子配位。铁络合物为四核星状簇合物[Fe4L6]，由一个中心Fe(III)离子与六个氧原子配位，三个Fe(III)离子形成一个等边三角形的角点。在铁、钴、镍、铜、锌和镉的醋酸盐存在下，用pBR322质粒DNA测定了游离配体H_2L的金属介导的DNA切割能力。H_2L与铜(II)盐结合后，DNA发生明显的断裂。通过UV-Vis滴定和分子对接研究了该配体与DNA的相互作用，结果表明该配体在DNA的小凹槽中具有良好的对接作用。
Three tetranuclear clusters, Zn(II), Ni(II) and Fe(III), have been prepared using a new chromene-based Schiff base ligand (H2L) derived from the condensation of 2-aminophenol and 5-hydroxy-2,2-dimethyl-2H-chromene-6-carbaldehyde. The structures of the tetranuclear clusters were determined by single crystal X-ray diffraction and mass spectrometric analyses. The crystallographic data indicates that the Zn and Ni clusters have similar structures [M4L4(THF)2] and contain a defective dicubane core, with each ligand coordinated to one metal ion through three donor atoms. The iron complex was obtained as a tetranuclear star shaped cluster [Fe4L6], consisting of a central Fe(III) ion coordinated to six oxygen atoms, with three Fe(III) ions forming the corners of an equilateral triangle. The metal-mediated DNA cleavage ability of the free ligand, H2L, was determined using pBR322 plasmid DNA in the presence of Fe, Co, Ni, Cu, Zn and Cd acetate salts. H2L in combination with the Cu(II) salt resulted in significant DNA cleavage. The interaction of the ligand with DNA was investigated by UV–Vis titrations and molecular docking studies, which indicated favorable docking in the minor groove of DNA.