Effects of Therapeutic Hypothermia Combined with Other Neuroprotective Strategies on Ischemic Stroke: Review of Evidence.
Effects of Therapeutic Hypothermia Combined with Other Neuroprotective Strategies on Ischemic Stroke: Review of Evidence.
复制标题
低温治疗联合其他神经保护策略对缺血性中风的影响：证据回顾
DOI：
10.14336/ad.2017.0628
复制
发表时间：
2018-06
影响因子：
7.4
通讯作者：
Ji X
中科院分区：
文献类型：
--
作者：
Zhang Z;Zhang L;Ding Y;Han Z;Ji X
缺血性卒中是全球死亡和残疾的主要原因，其发病率正在增加。美国食品和药物管理局批准的急性缺血性卒中的唯一治疗方法是重组组织型纤溶酶原激活剂溶栓治疗。作为一种替代方法，治疗性低温在临床前和小型临床研究中显示出了良好的潜力，但在大型临床研究中基本失败。这促使临床医生探索治疗性低温与其他神经保护策略的结合。本文综述了临床前和临床进展，以开发高效的联合治疗，包括脑卒中患者的低温。
Ischemic stroke is a major cause of death and disability globally, and its incidence is increasing. The only treatment approved by the US Food and Drug Administration for acute ischemic stroke is thrombolytic treatment with recombinant tissue plasminogen activator. As an alternative, therapeutic hypothermia has shown excellent potential in preclinical and small clinical studies, but it has largely failed in large clinical studies. This has led clinicians to explore the combination of therapeutic hypothermia with other neuroprotective strategies. This review examines preclinical and clinical progress towards developing highly effective combination therapy involving hypothermia for stroke patients.