Steady-state diffusion-weighted imaging of in vivo knee cartilage
Steady-state diffusion-weighted imaging of in vivo knee cartilage
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DOI：
10.1002/mrm.10696
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发表时间：
2004-02-01
影响因子：
3.3
通讯作者：
Pauly, JM
中科院分区：
文献类型：
--
作者：
Miller, KL;Hargreaves, BA;Pauly, JM
Diffusion-weighted imaging (DWI) has strong potential as a diagnostic for early cartilage damage, with clinical impact for diseases such as osteoarthritis. However, in vivo DWI of cartilage has proven difficult with conventional methods due to the short T-2. This work presents a 3D steady-state DWI sequence that is able to image short-T-2 species with high SNR. When combined with 2D navigator correction of motion-induced phase artifacts, this method enables high resolution in vivo DWI of cartilage. In vivo knee images in healthy subjects are presented with high SNR (SNR = 110) and submillimeter in-plane resolution (0.5 x 0.7 x 3.0 mm(3)). A method for fitting the diffusion coefficient is presented which produces fits within 10% of literature values. This method should be applicable to other short-T-2 tissues, such as muscle, which are difficult to image using traditional DWI methods. (C) 2004 Wiley-Liss, Inc.
