Fine-tuned shuttles for bone morphogenetic proteins.
Fine-tuned shuttles for bone morphogenetic proteins.
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骨形态发生蛋白的微调梭。
DOI：
10.1016/j.gde.2013.04.012
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发表时间：
2013
影响因子：
4
通讯作者：
Serpe,Mihaela
中科院分区：
文献类型：
--
作者：
Wharton,KristiA;Serpe,Mihaela
骨形态发生蛋白 (BMP) 是有效的分泌信号因子，可通过细胞表面的受体复合物结合触发 Smad 转录调节因子的磷酸化。由此产生的靶基因表达变化会影响发育和组织稳态过程中的关键细胞反应。 BMP 活性在时间和空间上受到分泌调节剂的严格调节，这些调节剂控制 BMP 细胞外分布和受体结合的可用性。这种细胞外调节是 BMP 作为形态发生素发挥作用和/或形成形态发生素活性梯度的关键。在这里，我们回顾了用于控制 BMP 配体在不同几何形状的组织中分布的穿梭系统，这些组织在不同的时间限制下发育。我们讨论了采用 BMP 穿梭特定策略的生物学优势以及不同配体形式的作用。
Bone morphogenetic proteins (BMPs) are potent secreted signaling factors that trigger phosphorylation of Smad transcriptional regulators through receptor complex binding at the cell-surface. Resulting changes in target gene expression impact critical cellular responses during development and tissue homeostasis. BMP activity is tightly regulated in time and space by secreted modulators that control BMP extracellular distribution and availability for receptor binding. Such extracellular regulation is key for BMPs to function as morphogens and/or in the formation of morphogen activity gradients. Here, we review shuttling systems utilized to control the distribution of BMP ligands in tissue of various geometries, developing under different temporal constraints. We discuss the biological advantages for employing specific strategies for BMP shuttling and roles of varied ligand forms.