Effects of dietary intake of soy protein and Isoflavones on cardiovascular disease risk factors in high risk, middle-aged men in Scotland
Effects of dietary intake of soy protein and Isoflavones on cardiovascular disease risk factors in high risk, middle-aged men in Scotland
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DOI：
10.1080/07315724.2004.10719347
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发表时间：
2004-02-01
影响因子：
3.5
通讯作者：
Yamori, Y
中科院分区：
文献类型：
--
作者：
Sagara, M;Kanda, T;Yamori, Y
目的：为了研究大豆蛋白和大豆黄酮对高风险中年苏格兰男性血压（BP）和胆固醇水平的影响，设计：一项随机、双盲、安慰剂对照、平行组饮食干预研究。61名血压和/或总胆固醇（TC）水平相对较高的45至59岁男性接受了饮食干预。干预：将含有至少20 g大豆蛋白和80 mg大豆酮的饮食与安慰剂饮食进行比较。结果：干预后两组患者24 h尿肌酐排泄量比较，差异有统计学意义。在含大豆饮食组中观察到收缩压（SBP）和舒张压（DBP）、TC和非高密度脂蛋白胆固醇（非HDL-C）较基线显著降低，但在含橄榄油的活性安慰剂组中未观察到。高密度脂蛋白胆固醇（HDL-C）的显着增加，观察在两个group.Conclusion：膳食摄入大豆蛋白（至少20克）和大豆黄酮（至少80毫克）5周将是有效的，在降低冠心病的风险，中年男性的高风险。
Objective: To investigate the effects of soy protein and isoflavones on blood pressure (BP) and cholesterol levels among high risk middle-aged Scottish men.Design: A randomized, double-blind, placebo-controlled, parallel-group dietary intervention studySetting: Inhabitants on Isles of Lewis and Harris in ScotlandSubjects: Sixty-one men with relatively higher BP and/or total cholesterol (TC) levels aged 45 to 59 went through the dietary intervention.Intervention: Diets containing at least 20 g of soy protein and 80 mg of isoflavones were compared to the placebo diets. Intervention period was 5 weeks duration.Results: Significant difference was found in 24-hour urinary isoflavone excretion between the two groups after intervention. Significant reductions from the baselines were observed in systolic BP (SBP) and diastolic BP (DBP), TC and non-high density lipoprotein cholesterol (non-HDL-C) in the soy-containing diet group, but not in the olive-oil containing active placebo group. Significant increases in high density lipoprotein cholesterol (HDL-C) were observed in both groups.Conclusion: Dietary intakes of soy protein (at least 20 g) and isoflavones (at least 80 mg) for 5 weeks would be effective in reducing CHD risk among high-risk, middle-aged men.