Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis
Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis
复制标题
DOI：
10.7554/elife.58227
复制
发表时间：
2020-07-07
期刊：
影响因子：
7.7
通讯作者：
Soundararajan, Venky
中科院分区：
文献类型：
--
作者：
Wagner, Tyler;Shweta, F. N. U.;Soundararajan, Venky
Understanding temporal dynamics of COVID-19 symptoms could provide fine-grained resolution to guide clinical decision-making. Here, we use deep neural networks over an institution-wide platform for the augmented curation of clinical notes from 77,167 patients subjected to COVID-19 PCR testing. By contrasting Electronic Health Record (EHR)-derived symptoms of COVID-19-positive (COVIDpos; n = 2,317) versus COVID-19-negative (COVIDneg; n = 74,850) patients for the week preceding the PCR testing date, we identify anosmia/dysgeusia (27.1-fold), fever/chills (2.6-fold), respiratory difficulty (2.2-fold), cough (2.2-fold), myalgia/arthralgia (2-fold), and diarrhea (1.4-fold) as significantly amplified in COVIDpos over COVIDneg patients. The combination of cough and fever/chills has 4.2-fold amplification in COVIDpos patients during the week prior to PCR testing, in addition to anosmia/dysgeusia, constitutes the earliest EHR-derived signature of COVID-19. This study introduces an Augmented Intelligence platform for the real-time synthesis of institutional biomedical knowledge. The platform holds tremendous potential for scaling up curation throughput, thus enabling EHR-powered early disease diagnosis.
