Accelerated Age-Related Arterial Stiffness in Systemic Lupus Erythematosus Patients
Accelerated Age-Related Arterial Stiffness in Systemic Lupus Erythematosus Patients
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DOI：
10.1097/rhu.0000000000000432
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发表时间：
2016-12-01
影响因子：
3.4
通讯作者：
Zhang, Shuyang
中科院分区：
文献类型：
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作者：
Ding, Fa Ming;Li, Mengtao;Zhang, Shuyang
背景 系统性红斑狼疮 (SLE) 患者的动脉僵硬度患病率有所增加，但动脉僵硬度随年龄增长而进展的机制尚未得到充分探索。 目的 调查 SLE 患者相对于健康对照的动脉僵硬度与年龄相关的进展情况。 方法 纳入中国 SLE 治疗与研究组 (CSTAR) 注册中心的 161 名女性 SLE 患者， 135 名年龄匹配的健康对照受试者参与了这项横断面调查。传统心血管危险因素和 SLE 相关参数在检查臂踝脉搏波速度 (baPWV) 当天进行评估。本研究使用 SAS 9.3 进行所有统计分析。利用线性回归和曲线回归模型来分析年龄和动脉僵硬度之间的关联。结果基于baPWV的动脉僵硬度在不同年龄组的SLE患者和对照之间以及SLE组内存在显着差异。每个年龄组（45 岁）的对照组 baPWV 增量分别为 30 cm/s、52 cm/s 和 121 cm/s，SLE 患者分别为 61 cm/s、132 cm/s 和 155 cm/s。曲线回归和线性回归揭示了与健康对照相比，SLE 患者动脉僵硬度增加的各种趋势。相对于健康对照，SLE 患者的年龄和动脉硬度之间的相关系数存在显着差异（相关系数分别为 0.46478 和 0.52612；t = 2.05；P = 0.0409）。多变量分析显示，年龄、平均血压（BP）（P < 0.0001）、红细胞沉降率（ESR）（P = 0.0073）、泼尼松疗程（P = 0.0144）和SLE疾病活动度（P = 0.0405）与SLE患者的动脉僵硬度相关。此外，与每个年龄组的对照组相比，这些患者表现出更早接触多种危险因素且频率更高（45 岁：OR = 3.6020）。 结论 相对于健康对照组，SLE 患者与年龄相关的动脉僵硬度进展机制有所不同。此外，随着年龄的增长，相对于健康对照组，系统性红斑狼疮患者的动脉硬化加速。
Background An increased prevalence of arterial stiffness in systemic lupus erythematosus (SLE) patients has been established, but the mechanisms of progression of arterial stiffness with increasing age have not been fully explored.Objectives To investigate age-related progression of arterial stiffness among SLE patients relative to healthy controls.Methods A total of 161 female SLE patients who were enrolled in the Chinese SLE Treatment and Research group (CSTAR) registry and 135 age-matched healthy control subjects participated in this cross-sectional investigation. Traditional cardiovascular risk factors and SLE-related parameters were assessed on the day that brachial-ankle pulse wave velocity (baPWV) was examined. SAS 9.3 was used to perform all statistical analyses in this study. Linear regression and curvilinear regression models were utilized to analyze the association between age and arterial stiffness.Results Arterial stiffness based on baPWV significantly differed between the SLE patients and controls in the different age groups, and within the SLE group. The baPWV increments for each age group (45) were 30 cm/s, 52 cm/s, and 121 cm/s for the controls and 61 cm/s, 132 cm/s, and 155 cm/s for the SLE patients, respectively. Curvilinear regression and linear regression revealed various trends of increased arterial stiffness among the SLE patients compared with the healthy controls. The correlation coefficients between age and arterial stiffness significantly differed among the SLE patients relative to the healthy controls (correlation coefficients of 0.46478 and 0.52612, respectively; t = 2.05; P = 0.0409). Multivariate analysis revealed that age, mean blood pressure (BP) (P < 0.0001), erythrocyte sedimentation rate (ESR) (P = 0.0073), prednisone course (P = 0.0144), and SLE disease activity (P = 0.0405) were associated with arterial stiffness among the SLE patients. Further, these patients exhibited earlier exposure to and higher frequencies of several risk factors compared with the controls in each age group (45 years: OR = 3.6020).Conclusions The mechanisms of the age-related progression of arterial stiffness differed among the SLE patients relative to the healthy controls. Furthermore, accelerated arterial stiffness was observed among the SLE patients relative to the healthy controls with advancing age.