Melatonin: a major regulator of the circadian rhythm of core temperature in humans.
Melatonin: a major regulator of the circadian rhythm of core temperature in humans.
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DOI：
10.1210/jcem.75.2.1639946
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发表时间：
1992-08
期刊：
影响因子：
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通讯作者：
A. Cagnacci;J. Elliott;S. Yen
中科院分区：
文献类型：
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作者：
A. Cagnacci;J. Elliott;S. Yen
核心体温（BTc）的昼夜节律，白天最高，晚上最低，通常与睡眠-觉醒周期相结合。松果体褪黑激素分泌在夜间同时发生，并且在黑暗期间由β-肾上腺素能受体的激活介导。研究了夜间褪黑激素分泌可能参与人体昼夜BTc节律调节的假设。褪黑激素和昼夜BTc节律之间的时间关系的特点是在12个年轻女性，通常夹带到光暗周期。在连续2天进行的双盲安慰剂对照实验中，通过在白天（n = 6）给予外源性褪黑激素（2.5 mg，口服）或通过β-肾上腺素能拮抗剂阿替洛尔（100 mg; n = 6）抑制内源性夜间褪黑激素分泌来操纵褪黑激素水平。分别以20分钟和10分钟的间隔监测血清褪黑激素水平和BTc。在夜班工人的褪黑激素和BTc的昼夜节律之间的时间关系进行了研究之前和之后夹带到一个颠倒的觉醒-睡眠周期。我们的数据表明，在正常携带的受试者，夜间褪黑激素分泌的时间过程和幅度与BTc的下降时间耦合（r = 0.97; P <0.00001）。同样的情况也发生在夜班工人身上，无论是在分离过程中还是在进入反向睡眠-觉醒周期后。与安慰剂相比，褪黑素的给药显著降低了白天的BTc（P <0.01），而褪黑素的抑制（阿替洛尔）减弱了夜间BTc的下降（P <0.01）。余弦分析表明，BTc昼夜节律的幅度降低了约40%，白天褪黑激素管理（P <0.05）和夜间褪黑激素抑制（P <0.02）。总之，褪黑激素和BTc的昼夜节律是反向耦合的。褪黑激素的低温特性是产生至少40%的昼夜BTc节律幅度的原因。褪黑素水平的操纵可能是临床上有用的BTc节律去稳态化的条件下，BTc节律。
The circadian rhythm of core body temperature (BTc), with maxima during the day and minima at night, is normally coupled with the sleep-wake cycle. Pineal melatonin secretion occurs contemporaneously during the nighttime hours and is mediated by the activation of beta-adrenergic receptors during darkness. The hypothesis that nocturnal melatonin secretion may be involved in the regulation of the human circadian BTc rhythm was examined. The temporal relationship between melatonin and the circadian BTc rhythm was characterized in 12 young women, normally entrained to the light-dark cycle. Melatonin levels were manipulated through the administration of exogenous melatonin (2.5 mg, orally) during the daytime (n = 6) or suppression of endogenous nocturnal melatonin secretion by the beta-adrenergic antagonist atenolol (100 mg; n = 6) in double blind placebo-controlled experiments conducted during 2 consecutive days. Serum melatonin levels and BTc were monitored at 20- and 10-min intervals, respectively. In a nightshift worker the temporal relationship between the circadian rhythm of melatonin and BTc was investigated before and after entrainment to a reversed wake-sleep cycle. Our data show that in normally entrained subjects, the time course and amplitude of nocturnal melatonin secretion were temporally coupled with the decline of BTc (r = 0.97; P less than 0.00001). The same occurred in the nightshift worker, both during the dissociation and after entrainment to the reversed sleep-wake cycle. Compared with placebo, administration of melatonin significantly reduced daytime BTc (P less than 0.01), and the suppression of melatonin (by atenolol) attenuated the nocturnal decline of BTc (P less than 0.01). Cosinor analysis showed that the amplitude of the circadian BTc rhythm was reduced by about 40% in response to both daytime melatonin administration (P less than 0.05) and nocturnal melatonin suppression (P less than 0.02). In conclusion, circadian rhythms of melatonin and BTc are inversely coupled. The demonstrated hypothermic properties of melatonin are accountable for the generation of at least 40% of the amplitude of the circadian BTc rhythm. Manipulation of melatonin levels might be clinically useful to resynchronize the BTc rhythm under conditions of BTc rhythm desynchronization.