Hippocampal volume and functional connectivity changes during the female menstrual cycle
Hippocampal volume and functional connectivity changes during the female menstrual cycle
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DOI：
10.1016/j.neuroimage.2015.06.012
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发表时间：
2015-09-01
期刊：
影响因子：
5.7
通讯作者：
Kuehn, Simone
中科院分区：
文献类型：
--
作者：
Lisofsky, Nina;Martensson, Johan;Kuehn, Simone
海马体体积已被证明对啮齿动物发情周期中雌激素和孕激素水平的变化很敏感。然而，关于荷尔蒙水平和大脑结构在人类月经周期过程中的协同变化，人们知之甚少。在这里，我们用包括几种脑成像方法和荷尔蒙评估的多方法方法来检验这种协变性。我们获得了21名自然周期妇女在其周期的四个时间点(卵泡早期、卵泡晚期、排卵和黄体期)的结构和功能扫描。在每个测量场合，对不同领域的激素血液浓度和认知表现进行评估。采用基于全脑体素的形态计量学和自由曲面方法对结构MRI图像进行处理。无论采用哪种方法，在卵泡晚期相对于卵泡早期，双侧海马体体积均有增加。海马体体积增大区域的灰质概率与同一区域的平均弥散系数较低相关。此外，我们观察到在卵泡晚期，海马体和双侧顶上叶之间有较高的功能连接。我们没有在认知任务中发现任何可靠的与循环相关的绩效差异。目前的结果表明，在人类月经周期的过程中，荷尔蒙的波动与海马体的结构和功能有关。(C)2015 Elsevier Inc.保留所有权利。
Hippocampal volume has been shown to be sensitive to variations in estrogen and progesterone levels across rodents' estrous cycle. However, little is known about the covariation of hormone levels and brain structure in the course of the human menstrual cycle. Here, we examine this covariation with a multi-method approach that includes several brain imaging methods and hormonal assessments. We acquired structural and functional scans from 21 naturally cycling women on four time points during their cycles (early follicular phase, late follicular phase, ovulation and luteal phase). Hormone blood concentrations and cognitive performance in different domains were assessed on each of the measurement occasions. Structural MRI images were processed by means of whole-brain voxel-based morphometry and FreeSurfer. With either method, bilateral increases in hippocampal volume were found in the late follicular phase relative to the early follicular phase. The gray matter probability in regions of hippocampal volume increase was associated with lower mean diffusivity in the same region. In addition, we observed higher functional connectivity between the hippocampi and the bilateral superior parietal lobe in the late follicular phase. We did not find any reliable cycle-related performance variations on the cognitive tasks. The present results show that hormonal fluctuations covary with hippocampal structure and function in the course of the human menstrual cycle. (C) 2015 Elsevier Inc. All rights reserved.