Effect of a fluid bolus on cardiovascular collapse among critically ill adults undergoing tracheal intubation (PrePARE): a randomised controlled trial
Effect of a fluid bolus on cardiovascular collapse among critically ill adults undergoing tracheal intubation (PrePARE): a randomised controlled trial
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DOI：
10.1016/s2213-2600(19)30246-2
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发表时间：
2019-12-01
影响因子：
76.2
通讯作者：
Rice, Todd W.
中科院分区：
文献类型：
--
作者：
Janz, David R.;Casey, Jonathan D.;Rice, Todd W.
背景 气管插管在危重成人的护理中很常见，并且经常并发低血压、心脏骤停或死亡。我们的目的是评估静脉推注液体的给药方式，以预防危重成人插管期间的心血管衰竭。方法我们在美国九个地点（八个 ICU 和一个急诊室）进行了一项务实、多中心、非盲式、随机试验。接受气管插管的危重成人（> = 18 岁）被随机分配（1:1，块大小为 2、4 和 6，按研究地点分层）要么静脉输注 500 mL 晶体溶液，要么不静脉推注液体。在意向治疗人群中评估的主要结局是心血管崩溃，定义为新的收缩压
Background Tracheal intubation is common in the care of critically ill adults and is frequently complicated by hypotension, cardiac arrest, or death. We aimed to evaluate administration of an intravenous fluid bolus to prevent cardiovascular collapse during intubation of critically ill adults.Methods We did a pragmatic, multicentre, unblinded, randomised trial in nine sites (eight ICUs and one emergency department) around the USA. Critically ill adults (>= 18 years) undergoing tracheal intubation were randomly assigned (1:1, block sizes of 2, 4, and 6, stratified by study site) to either an intravenous infusion of 500 mL of crystalloid solution or no fluid bolus. The primary outcome, assessed in the intention-to-treat population, was cardiovascular collapse, defined as a new systolic blood pressure