Counting cross-overs: characterizing meiotic recombination in mammals
Counting cross-overs: characterizing meiotic recombination in mammals
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DOI：
10.1093/hmg/9.16.2409
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发表时间：
2000-10-01
影响因子：
3.5
通讯作者：
Hunt, P
中科院分区：
文献类型：
--
作者：
Hassold, T;Sherman, S;Hunt, P
直到最近，我们对减数分裂重组的了解大多来自于对低等真核生物的研究，然而，在过去的几年里，已经确定了哺乳动物减数分裂重组途径的几个组成部分，并发展了新的分子和细胞学方法来分析哺乳动物的减数分裂。在这篇综述中，我们讨论了三个领域的最新进展：应用新技术研究个体减数分裂中重组的全基因组水平；分析哺乳动物重组途径的时间方面的研究；以及将人类三体的发生与减数分裂交换模式的改变联系起来的研究。
dUntil recently, most of our understanding of meiotic recombination has come from studies of lower eukaryotes, However, over the past few years several components of the mammalian meiotic recombination pathway have been identified, and new molecular and cytological approaches to the analysis of mammalian meiosis have been developed. In this review, we discuss recent advances in three areas: the application of new techniques to study genome-wide levels of recombination in individual meioses; studies analyzing temporal aspects of the mammalian recombination pathway; and studies linking the genesis of human trisomies to alterations in meiotic exchange patterns.