Human anterior cingulate cortex neurons encode cognitive and emotional demands
Human anterior cingulate cortex neurons encode cognitive and emotional demands
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DOI：
10.1523/jneurosci.2315-05.2005
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发表时间：
2005-09-14
影响因子：
5.3
通讯作者：
Lozano, AM
中科院分区：
文献类型：
--
作者：
Davis, KD;Taylor, KS;Lozano, AM
认知和情感需求的皮质机制和基质知之甚少。病变研究和功能成像涉及前扣带皮层（ACC）。尾侧ACC（cACC）已被牵连在认知过程中，如注意，显着性，干扰和反应竞争，主要是基于神经成像结果。为了验证这一假设，个别cACC神经元subserve这些功能，我们监测的cACC中的单细胞的神经元活动，而受试者从事心算任务，认知要求计数Stroop任务，和/或情绪Stroop干扰任务。我们现在报告了人类单个神经元的第一个直接测量结果，确定了一群cACC神经元，它们对认知要求高和低冲突的Stroop任务（包括那些具有情感效价的任务）的反应不同或分级。这些数据表明，cACC神经元可能是作为显着性检测器时，面对冲突和困难或情绪刺激，一致的cACC反应突然的感官，新颖的，任务相关的，或痛苦的刺激的神经成像结果。
The cortical mechanisms and substrates of cognitive and emotional demands are poorly understood. Lesion studies and functional imaging implicate the anterior cingulate cortex (ACC). The caudal ACC (cACC) has been implicated in cognitive processes such as attention, salience, interference, and response competition, mostly on the basis of neuroimaging results. To test the hypothesis that individual cACC neurons subserve these functions, we monitored neuronal activity from single cells in the cACC while subjects were engaged in a mental arithmetic task, the cognitively demanding counting Stroop task, and/or the emotional Stroop interference task. We now report the first direct measures of single neurons in humans identifying a population of cACC neurons that respond differentially or in a graded manner to cognitively demanding high- and low- conflict Stroop tasks, including those with emotional valence. These data indicate that cACC neurons may be acting as salience detectors when faced with conflict and difficult or emotional stimuli, consistent with neuroimaging results of cACC responses to abrupt sensory, novel, task-relevant, or painful stimuli.