Immunopathological characterization of selected mouse models of inflammatory bowel disease: Comparison to human disease.
Immunopathological characterization of selected mouse models of inflammatory bowel disease: Comparison to human disease.
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DOI：
10.1016/j.pathophys.2014.05.002
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发表时间：
2014-11-01
期刊：
影响因子：
--
通讯作者：
Grisham, Matthew B
中科院分区：
文献类型：
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作者：
Jones-Hall, Yava L;Grisham, Matthew B
炎症性肠病（IBD）是一种多因素病因的慢性复发性疾病。IBD的两种主要疾病是克罗恩病（CD）和溃疡性结肠炎（UC）。这两种实体被假设发生在遗传易感个体由于微生物的改变和环境的贡献。然而，这两种疾病的确切发病机制尚不清楚。已经开发了多种CD和UC小鼠模型来研究这些疾病的发病机制并评价治疗方式。广义上讲，小鼠模型可分为4类：基因工程、免疫操作、自发和糜烂/化学诱导。没有一种小鼠模型完全概括CD或UC的免疫病理学，然而，每种模型与人IBD具有特定的相似性，并为IBD发病机制的特定细节提供了优势。在这里，我们讨论了每个类别中更常用的模型，并批判性地评估了与CD或UC相比诱导的免疫病理学，以及与每个模型相关的优点和缺点。
Inflammatory bowel diseases (IBD) are chronic, relapsing conditions of multifactorial etiology. The two primary diseases of IBD are Crohn's disease (CD) and ulcerative colitis (UC). Both entities are hypothesized to occur in genetically susceptible individuals due to microbial alterations and environmental contributions. The exact etiopathogenesis, however, is not known for either disease. A variety of mouse models of CD and UC have been developed to investigate the pathogenesis of these diseases and evaluate treatment modalities. Broadly speaking, the mouse models can be divided into 4 categories: genetically engineered, immune manipulated, spontaneous and erosive/chemically induced. No one mouse model completely recapitulates the immunopathology of CD or UC, however each model possesses particular similarities to human IBD and offers advantageous for specific details of IBD pathogenesis. Here we discuss the more commonly used models in each category and critically evaluate how the immunopathology induced compares to CD or UC, as well as the advantages and disadvantages associated with each model.