Laboratory-acquired brucellosis:: a Spanish national survey
Laboratory-acquired brucellosis:: a Spanish national survey
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DOI：
10.1016/j.jhin.2005.02.018
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发表时间：
2005-09-01
影响因子：
6.9
通讯作者：
González, MJ
中科院分区：
文献类型：
--
作者：
Bouza, E;Sánchez-Carrillo, C;González, MJ
在西班牙的1240名临床微生物实验室工作人员中进行了回顾性邮政调查。总体而言，75人（43名微生物学家和32名技术人员）患有实验室获得性布鲁氏菌病（LAB）。考虑到总的回复数量（N=628），LAB的比率为11.9%。患LAB的风险与布鲁氏菌分离株的数量明显相关。每一年。60个案例（80%）确认生物安全措施有重大突破。在9起案件中，处理被认为是安全的，在6起案件中，感染源不明。所有病例的诊断均基于血清学。在51例（68%）中，血培养证实了诊断。采用多种方案治疗75例LAB病例。四环素和链霉素的组合是最常用的方案（35例患者），其次是四环素和利福平的组合（19例）。仅10例患者（13.3%）出现并发症。根据抗菌方案，未观察到分离度差异。微生物。实验室工作人员仍然有患上LAB的危险。提高安全性似乎是最好的预防手段。(c)2005年，医院感染协会。由爱思唯尔有限公司出版。保留所有权利。
A retrospective postal survey was carried out among 1240 clinical microbiology laboratory workers in Spain. Overall, 75 (43 microbiologists and 32 technicians) had suffered from laboratory-acquired brucellosis (LAB). Considering the total number of replies (N=628), the rate of LAB was 11.9%. The risk of suffering from LAB was clearly related to the number of isolates of Brucella spp. per year. A major break in biosafety measures was recognized in 60 cases (80%). In nine cases, processing was considered to be secure, and in six cases, the source of infection was unknown. Diagnosis was based on serology in all cases. In 51 cases (68%), blood cultures confirmed diagnosis. A variety of regimens were used to treat the 75 LAB cases. The combination of tetracycline and streptomycin was the most commonly used regimen (in 35 patients), followed by the combination of tetracycline and rifampicin (in 19 cases). Only 10 patients (13.3%) suffered from complications. No differences in resolution were observed according to the antimicrobial regimen. Microbiological. laboratory workers are stilt at risk of developing LAB. Improvements in safety seem to be the best means of prevention. (c) 2005 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.