Jiangsu Four Cancers Study: a large case-control study of lung, liver, stomach, and esophageal cancers in Jiangsu Province, China.
Jiangsu Four Cancers Study: a large case-control study of lung, liver, stomach, and esophageal cancers in Jiangsu Province, China.
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江苏四种癌症研究：中国江苏省肺癌、肝癌、胃癌和食道癌的大型病例对照研究。
DOI：
10.1097/cej.0000000000000262
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Zhang,Zuo-Feng
中科院分区：
文献类型：
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作者：
Zhao,Jin-Kou;Wu,Ming;Kim,ClaireH;Jin,Zi-Yi;Zhou,Jin-Yi;Han,Ren-Qiang;Yang,Jie;Zhang,Xiao-Feng;Wang,Xu-Shan;Liu,Ai-Ming;Gu,Xiaoping;Su,Ming;Hu,Xu;Sun,Zheng;Li,Gang;Li,Liming;Mu,Lina;Zhang,Zuo-Feng
癌症是全球和中国的主要公共卫生负担。中国最常见的癌症相关死亡是肺癌、肝癌、胃癌和食道癌。以往中国癌症流行病学研究往往受到样本量小、测量不一致以及缺乏精确和准确数据的限制。江苏四癌研究（JFC）是一项基于人群的病例对照研究，旨在获得一致和高质量的数据，以调查与中国四种主要癌症相关的生活方式，行为，环境和遗传因素。本文的目的是描述JFC研究的总体设计，并报告癌症主要危险因素的选定结果。流行病学数据收集从2003年到2010年，通过面对面访谈，使用结构式问卷和血液样本。非条件Logistic回归用于估计推定的危险因素与肺癌、肝癌、胃癌和食道癌风险的相关性。该研究包括2871例肺癌病例，2018例肝癌病例，2969例食管癌病例，2216例胃癌病例和8019例社区对照。低文化程度、低收入水平、吸烟、饮酒和癌症家族史被证实是这些主要癌症的危险因素。JFC研究是中国人群中最大的癌症病例对照研究之一，将为中国四大癌症的未来研究提供丰富的资源。
Cancer is a major public health burden both globally and in China. The most common cancer-related deaths in China are attributable to cancers of the lung, liver, stomach, and esophagus. Previous epidemiologic studies on cancer in China have often been limited by small sample sizes, inconsistent measurements, and lack of precise and accurate data. The Jiangsu Four Cancers (JFC) Study is a population-based case–control study carried out in an effort to obtain consistent and high-quality data to investigate the life style, behavioral, environmental, and genetic factors associated with the four major cancers in China. The aim of this paper is to describe the overall design of the JFC Study and report selected findings on the major risk factors for cancers. Epidemiologic data were collected from 2003 to 2010 through in-person interviews using a structured questionnaire and blood samples were drawn. Unconditional logistic regression was used to estimate the associations of putative risk factors with risks of cancers of the lung, liver, stomach, and esophagus. The study included 2871 lung cancer cases, 2018 liver cancer cases, 2969 esophageal cancer cases, 2216 stomach cancer cases, and 8019 community controls. Low educational level, low income level, tobacco smoking, alcohol drinking, and family history of cancer were confirmed as risk factors for these major cancers. The JFC Study is one of the largest case–control studies of cancers in the Chinese population and will serve as a rich resource for future research on the four major cancers in China.