Exercise testing to evaluate patients with pulmonary vascular disease.
Exercise testing to evaluate patients with pulmonary vascular disease.
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运动测试评估肺血管疾病患者。
DOI：
10.1164/arrd.1984.129.2p2.s93
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Fishman,AP
中科院分区：
文献类型：
--
作者：
Janicki,JS;Weber,KT;Likoff,MJ;Fishman,AP
肺血管疾病患者总是具有升高的肺血管阻力。疾病过程越严重和广泛，抵抗力的提高就越大。不幸的是，这些患者只有在疾病严重发展后才会出现劳力性疲劳和呼吸困难的症状以及右心衰竭的迹象。早期检测的方法实际上是不存在的，临床或非侵入性的严重程度的估计往往是不可靠的，因为在患病的肺循环中的高阻力流动将不利地改变心输出量对运动的反应，从而损害患者的有氧能力，运动试验可能被证明是有用的检测和评估肺血管疾病的严重程度。我们研究了运动试验在不同严重程度和起源的肺血管疾病患者中的作用。血流动力学监测与呼吸气体交换测量相结合，以检查这些问题（1）。在这份报告中，我们回顾了这一经验，这表明肺血管疾病的严重程度可以通过无创评估的最大02摄取和无氧阈值在渐进式直立跑台运动期间达到确定。
Patients with pulmonary vascular disease invariably have an elevated pulmonary vascular resistance. The more severe and extensive the disease process, the greater this elevation in resistance. Unfortunately, these patients experience symptoms of exertional fatigue and breathlessness and signs of right heart failure only after their disease is far advanced. Methods of early detection are virtually nonexistent and clinical or noninvasive estimates of severity are often unreliable.Because the high resistance to flow in the diseased pulmonary circulation will adversely alter the cardiac output response to exercise and thereby compromise the aerobic capacity of the patient, exercise testing may prove useful in detecting and assessing the severity of pulmonary vascular disease. We have investigated the usefulness of exercise testing in patients with pulmonary vascular disease of varying severity and origin. Hemodynamic monitoring was combined with the measurement of respiratory gas exchange to examine these issues (1). In this report we review this experience, which indicates that the severity of pulmonary vascular disease can be determined through the noninvasive assessment of the maximal 02 uptake and anaerobic threshold attained during progressive upright treadmill exercise.