Oxytocin in the nucleus accumbens shell reverses CRFR2-evoked passive stress-coping after partner loss in monogamous male prairie voles.
Oxytocin in the nucleus accumbens shell reverses CRFR2-evoked passive stress-coping after partner loss in monogamous male prairie voles.
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DOI：
10.1016/j.psyneuen.2015.11.011
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发表时间：
2016-02
影响因子：
3.7
通讯作者：
Young LJ
中科院分区：
文献类型：
--
作者：
Bosch OJ;Dabrowska J;Modi ME;Johnson ZV;Keebaugh AC;Barrett CE;Ahern TH;Guo J;Grinevich V;Rainnie DG;Neumann ID;Young LJ
失去伴侣会对心理健康产生严重影响。在这里，我们探讨了神经机制的基础上增加被动压力应对，抑郁样行为的指示，在一夫一妻制的雄性草原田鼠的女性伴侣的损失。我们证明，促肾上腺皮质激素释放因子受体2（CRFR2）在丘脑核壳介导的社会损失引起的被动应对。此外，我们表明，合作伙伴的损失损害催产素系统通过多种机制。最后，我们提供的证据CRFR2和催产素系统的相互作用，在调解的情感后果的合作伙伴损失。我们的研究结果表明，慢性激活的CRFR2和抑制纹状体催产素信号后，合作伙伴损失的结果在一个厌恶的情绪状态，可能会分享潜在的机制与丧亲之痛。我们认为，催产素信号的抑制可能是适应在短期分离，以鼓励与合作伙伴团聚，并可能已经发展到维持长期的伙伴关系。此外，针对这些系统的治疗策略应考虑用于治疗社会损失介导的抑郁症。
Loss of a partner can have severe effects on mental health. Here we explore the neural mechanisms underlying increased passive stress-coping, indicative of depressive-like behavior, following the loss of the female partner in the monogamous male prairie vole. We demonstrate that corticotropin-releasing factor receptor 2 (CRFR2) in the nucleus accumbens shell mediates social loss-induced passive coping. Further, we show that partner loss compromises the oxytocin system through multiple mechanisms. Finally, we provide evidence for an interaction of the CRFR2 and oxytocin systems in mediating the emotional consequences of partner loss. Our results suggest that chronic activation of CRFR2 and suppression of striatal oxytocin signaling following partner loss result in an aversive emotional state that may share underlying mechanisms with bereavement. We propose that the suppression of oxytocin signaling is likely adaptive during short separations to encourage reunion with the partner and may have evolved to maintain long-term partnerships. Additionally, therapeutic strategies targeting these systems should be considered for treatment of social loss-mediated depression.