VARIATION IN ISOMETRIC TENSION WITH SARCOMERE LENGTH IN VERTEBRATE MUSCLE FIBRES
VARIATION IN ISOMETRIC TENSION WITH SARCOMERE LENGTH IN VERTEBRATE MUSCLE FIBRES
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DOI：
10.1113/jphysiol.1966.sp007909
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发表时间：
1966-01-01
影响因子：
5.5
通讯作者：
JULIAN, FJ
中科院分区：
文献类型：
--
作者：
GORDON, AM;HUXLEY, AF;JULIAN, FJ
研究了青蛙横纹肌单纤维中等长破伤风张力随肌节长度的变化，并采取特殊预防措施，以确保所研究纤维部分内肌节长度的均匀性。曲线的峰值由2.05和2.2μ的肌节长度之间的平台组成；该平台上方的张力下降比之前发现的更陡峭，而平台下方的张力下降在肌节长度约为 1.67 μ 处突然变得更陡峭。滑丝理论解释了这种长度-张力关系的许多特征。每根细丝上的张力由每个桥的相同贡献组成，每个桥与平台中相邻的粗丝重叠并且长度更大。在此范围内可忽略不计的缩短的内部阻力随着低于平台的缩短而变得逐渐变得更加重要。
The variation of isometric tetanus tension with sarcomere length in single fibers from frog striated muscle was investigated with special precautions to insure uniformity of sarcomere length within the part of the studied fiber. The peak of the curve consisted of a plateau between sarcomere lengths of 2.05 and 2.2 [mu]; the decline of tension above this plateau is steeper than previously found and the decline of tension below the plateau becomes suddenly steeper at a sarcomere length of about 1.67 [mu]. Many features of this length-tension relation explained by the slidtog-filament theory. The tension on each thinf ilament is made up of equal contributions from each bridge which it overlaps on adjacent thick filaments in the plateau and at greater lengths. Internal resistance to shortening which is negligible in this range becomes progressievly more important with shortening below the plateau.