Tumor-Infiltrating Mast Cells in Colorectal Cancer as a Poor Prognostic Factor
Tumor-Infiltrating Mast Cells in Colorectal Cancer as a Poor Prognostic Factor
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结直肠癌中肿瘤浸润性肥大细胞是不良预后因素
DOI：
10.1177/1066896912448836
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发表时间：
2013-04-01
影响因子：
1.2
通讯作者：
Lan, Ping
中科院分区：
文献类型：
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作者：
Wu, Xianrui;Zou, Yifeng;Lan, Ping
本研究旨在探讨肿瘤浸润性肥大细胞（TIM）在结直肠癌（CRC）患者中的临床/预后意义。免疫组化法检测325例I ~ III期结直肠癌组织中TIM浸润情况。通过X-tile程序评估TIM密度的最佳切割点。结直肠癌组织中的TIM浸润明显高于正常结直肠组织。根据X-tile程序，当TIM密度大于8.0/高倍视野时，确定CRC中高TIM浸润的分界点。TIM密度和临床病理变量之间的相关性分析表明，TIM浸润与性别，淋巴结状态，和美国癌症联合委员会阶段显着相关。多因素考克斯回归分析显示，高TIM浸润是总生存期和无病生存期的危险因素。总之，高TIM浸润可能是预测CRC患者生存率差的独立和有用的生物标志物。
The purpose of this study is to investigate the clinical/prognostic significance of tumor-infiltrating mast cells (TIMs) in patients with colorectal cancer (CRC). TIM infiltration in 325 stage I to III CRC specimens was detected by immunohistochemistry. The optimal cutpoint of TIM density was assessed by the X-tile program. TIM infiltration in CRC was significantly higher than in normal colorectal tissues. According to the X-tile program, the cutpoint for high TIM infiltration in CRC was determined when TIM density was more than 8.0 per high-power field. Correlation analysis between TIM density and clinicopathological variables demonstrated that TIM infiltration was significantly associated with gender, nodal status, and American Joint Committee on Cancer stage. Multivariate Cox regression analysis showed that high TIM infiltration was a risk factor for both overall survival and disease-free survival. Taken together, high TIM infiltration can be an independent and useful biomarker for predicting the poor survival of patients with CRC.