Amelioration of autoimmune arthritis by naringin through modulation of T regulatory cells and Th1/Th2 cytokines
Amelioration of autoimmune arthritis by naringin through modulation of T regulatory cells and Th1/Th2 cytokines
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DOI：
10.1016/j.cellimm.2014.01.001
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发表时间：
2014-02-01
影响因子：
4.3
通讯作者：
Abd-Allah, Adel R. A.
中科院分区：
文献类型：
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作者：
Ahmad, Sheikh Fayaz;Zoheir, Khairy M. A.;Abd-Allah, Adel R. A.
柚苷是一种在葡萄柚和其他柑橘类水果中发现的众所周知的黄烷酮糖苷，被确定为有效的抗炎化合物。我们研究了柚皮苷对关节炎炎症关键介质的影响，即T细胞亚群、CD 4（+）GITR（+）表达细胞、CD 4（+）CD 25（+）Foxp 3（+）（Treg）、Th 1/Th 2细胞因子和炎症介质。我们将Balb/c小鼠（p.o.）柚苷（20、40、80 mg/kg）灌胃14 d。与溶剂处理和关节炎对照小鼠相比，柚苷处理显示T细胞水平、CD 4（+）GITR（+）、Th 1细胞因子和炎症介质表达显著降低。相反，柚苷处理导致Treg和Th 2细胞因子水平显著上调。因此，柚苷诱导的T细胞抑制，各种促炎细胞因子和促进细胞浸润到关节的炎症介质可能有助于其抗关节炎活性。我们的数据表明，柚苷减少了小鼠的AIA，它可能是一个潜在的替代/辅助治疗类风湿关节炎。(C)2014爱思唯尔公司All rights reserved.
Naringin, a well-known flavanone glycoside found in grapefruit and other citrus fruits, was determined to be an effective anti-inflammatory compound. We investigated the effect of naringin on the key mediators of arthritic inflammation, namely T cell subsets, CD4(+)GITR(+) expressing cells, CD4(+)CD25(+)Foxp3(+) (Treg), Th1/Th2 cytokines and inflammatory mediators. We treated Balb/c mice (p.o.) with naringin (20, 40 and 80 mg/kg) for 14 days. Compared with the vehicle-treated and arthritic-control mice, the naringin treatment demonstrated a considerable decrease in the level of T cells, CD4(+)GITR(+), Th1 cytokine and inflammatory mediator expressions. In contrast, naringin treatment resulted in significantly up-regulated Treg and Th2 cytokine levels. Therefore, the naringin-induced inhibition of the T cells, various pro-inflammatory cytokines and inflammatory mediators that facilitate cellular infiltration into the joints might have contributed to its anti-arthritic activity. Our data suggest that naringin diminished the AIA in mice and it could be a potential alternative/adjunct treatment for RA. (C) 2014 Elsevier Inc. All rights reserved.