Klk8, a multifunctional protease in the brain and skin: analysis of knockout mice
Klk8, a multifunctional protease in the brain and skin: analysis of knockout mice
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DOI：
10.1515/bc.2010.034
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发表时间：
2010-04
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影响因子：
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通讯作者：
S. Yoshida
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文献类型：
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作者：
S. Yoshida
Klk 8是一种底物特异性有限的胰蛋白酶丝氨酸蛋白酶。Klk8 mRNA在许多发育器官中表达，而其表达仅限于成年人的有限区域，包括海马。在海马中，Klk8参与活动依赖性突触变化，例如长时程增强，发现其在Klk8敲除（KO）小鼠中被抑制。少突胶质细胞在中枢神经系统损伤后仅表达Klk 8 mRNA。皮肤的表皮是表现出高水平KLK 8表达的组织之一。Klk8可能通过降解连接表皮层的粘附分子参与脱屑。Klk8因此可能参与组织发育和重排。
Abstract Klk8 is a tryptic serine protease with limited substrate specificity. Klk8 mRNA is expressed in many developing organs, whereas its expression is confined to limited regions, including the hippocampus, in adults. In the hippocampus, Klk8 is involved in activity-dependent synaptic changes such as long-term potentiation, which was found to be suppressed in Klk8 knockout (KO) mice. Oligodendrocytes only expressed Klk8 mRNA after injury to the central nervous system. The epidermis of the skin is one of the tissues that exhibits a high level of KLK8 expression. Klk8 might be involved in desquamation through the degradation of adhesive molecules that connect layers of the epidermis. Klk8 might thus be involved in tissue development and rearrangement.