Air pollution and heart rate variability among the elderly in Mexico City
Air pollution and heart rate variability among the elderly in Mexico City
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DOI：
10.1097/01.ede.0000081999.15060.ae
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发表时间：
2003-09-01
期刊：
影响因子：
5.4
通讯作者：
Romieu, I
中科院分区：
文献类型：
--
作者：
Holguin, F;Téllez-Rojo, MM;Romieu, I
背景资料：悬浮颗粒物和臭氧与不同程度的心脏自主神经功能障碍有关。方法：在墨西哥城，疗养院的居民每隔一天接受一次心率变异性分析，持续3个月。每天在疗养院测量室内和室外PM2.5（直径小于2.5 mm的颗粒物）。臭氧和其他大气污染物的水平，从附近的自动监测station.Results：最初的42个筛选的参与者，34（81%）在研究期间进行了跟踪。室内PM2.5的24小时平均水平介于15至67 mug/m（3）之间，室外PM2.5介于9至87 mug/m（3）之间。每日1小时最高臭氧水平为47至228 ppb。在调整年龄和心率后，我们观察到心率变异性的高频成分和PM2.5的平均24小时浓度大幅下降。高血压的参与者有相当大的减少，在他们的高频心率变异性（高频心率变异性）组件在臭氧和PM2.5 exposure.Conclusions：我们的研究结果表明，环境水平的PM2.5和臭氧可以减少高频成分的心率变异性在老年人生活在墨西哥城和潜在的高血压受试者特别容易受到这种影响。
Background: Suspended particles and ozone have been associated with varying degrees of cardiac autonomic dysfunction.Methods: In Mexico City, residents from a nursing home underwent heart rate variability analysis every other day for 3 months. Indoor and outdoor PM2.5 (particulate matter less than 2.5 mm in diameter) were measured daily at the nursing home. Levels of ozone and other atmospheric pollutants were obtained from a nearby automated monitoring station.Results: Of the initial 42 screened participants, 34 (81%) were followed during the study period. The 24-hour average levels of indoor PM2.5 ranged from 15 to 67 mug/m(3), and outdoor PM2.5 ranged from 9 to 87 mug/m(3). Daily 1-hour maximum ozone levels ranged from 47 to 228 ppb. After adjusting for age and heart rate, we observed a strong decrease in the high frequency component of heart rate variability and the average 24-hour concentrations of PM2.5. Participants with hypertension had considerably larger reductions in their HF-HRV (high frequency-heart rate variability) component in relation to both ozone and PM2.5 exposure.Conclusions: Our results suggest that ambient levels of PM2.5 and ozone can reduce the high-frequency component of heart rate variability in elderly subjects living in Mexico City and that subjects with underlying hypertension are particularly susceptible to this effect.