5-HYDROXYMETHYLCYTOSINE DNA GLYCOSYLASE ACTIVITY IN MAMMALIAN TISSUE
5-HYDROXYMETHYLCYTOSINE DNA GLYCOSYLASE ACTIVITY IN MAMMALIAN TISSUE
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DOI：
10.1016/s0006-291x(88)80489-3
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发表时间：
1988-03-30
影响因子：
3.1
通讯作者：
TEEBOR, GW
中科院分区：
文献类型：
--
作者：
CANNON, SV;CUMMINGS, A;TEEBOR, GW
小牛胸腺提取物可实现 T2 噬菌体 DNA 酶促释放 5-羟甲基胞嘧啶。与之前描述的 5-羟甲基尿嘧啶 DNA 糖基化酶一样，在细菌提取物中未检测到 5-羟甲基胞嘧啶 DNA 糖基化酶。这些活性的系统发育分布表明它们的主要功能是维持分化组织中的甲基胞嘧啶残基。
The enzymatic release of 5-hydroxymethylcytosine from T2 bacteriophage DNA was effected by an extract of calf thymus. Like the previously described 5-hydroxymethyluracil DNA glycosylase, 5-hydromethylcytosine DNA glycosylase was not detectable in bacterial extracts. The phylogenetic distribution of these activities indicates that their primary function is the maintenance of methylcytosine residues in differentiated tissue.