Gut Microbiota in Tumor Microenvironment: A Critical Regulator in Cancer Initiation and Development as Potential Targets for Chinese Medicine
Gut Microbiota in Tumor Microenvironment: A Critical Regulator in Cancer Initiation and Development as Potential Targets for Chinese Medicine
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DOI：
10.1142/s0192415x21500270
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发表时间：
2021-01-01
影响因子：
5.7
通讯作者：
Du, Jun-Rong
中科院分区：
文献类型：
--
作者：
Wang, Li;Peng, Fu;Du, Jun-Rong
癌症是一种死亡率和致残率都很高的疾病。癌症不仅由癌细胞组成，还包括周围的微环境和肿瘤微环境（TME），它们不断与肿瘤细胞相互作用，以支持肿瘤的发展和进展。在过去的十年中，越来越多的证据表明，微生物群深刻影响癌症的发生和发展。大多数研究集中在肠道微生物群，因为肠道拥有最大的微生物集合。肠道微生物群包括胃肠道中的细菌、病毒、原生动物、古生菌和真菌，影响各种类型癌症中的DNA损伤、宿主免疫应答和慢性炎症（即，结肠癌、胃癌和乳腺癌）。值得注意的是，肠道生态失调可以重塑肿瘤微环境，使其有利于肿瘤生长。近年来，中医药在肿瘤治疗中的作用日益受到重视，具有生物活性的天然化合物被认为是潜在的抑制肿瘤发生和发展的候选药物。有趣的是，最近的研究表明，中药可以通过调节肠道微生物群来预防和抑制早期癌症的进展。本文就肿瘤微环境中肠道菌群作为中医药潜在靶点的意义作一综述。
Cancer is a disease with a high mortality and disability rate. Cancer consists not only of cancer cells, but also of the surrounding microenvironment and tumor microenvironment (TME) constantly interacting with tumor cells to support tumor development and progression. Over the last decade, accumulating evidence has implicated that microbiota profoundly influences cancer initiation and progression. Most research focuses on gut microbiota, for the gut harbors the largest collection of microorganisms. Gut microbiota includes bacteria, viruses, protozoa, archaea, and fungi in the gastrointestinal tract, affecting DNA damage, host immune response and chronic inflammation in various types of cancer (i.e., colon cancer, gastric cancer and breast cancer). Notably, gut dysbiosis can reshape tumor microenvironment and make it favorable for tumor growth. Recently, accumulating studies have attached the importance of traditional Chinese medicine (TCM) to cancer treatments, and the bioactive natural compounds have been considered as potential drug candidates to suppress cancer initiation and development. Interestingly, more recent studies demonstrate that TCM could potentially prevent and suppress early-stage cancer progression through the regulation of gut microbiota. This review is on the purpose of exhausting the significance of gut microbiota in the tumor microenvironment as potential targets of Chinese medicine.