Molecular epidemiology of the heterosexual HIV-1 transmission in Kunming, Yunnan Province of China suggests origin from the local IDU epidemic
Molecular epidemiology of the heterosexual HIV-1 transmission in Kunming, Yunnan Province of China suggests origin from the local IDU epidemic
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DOI：
10.1089/aid.2005.21.977
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发表时间：
2005-11-01
影响因子：
1.5
通讯作者：
Takebe, Y
中科院分区：
文献类型：
--
作者：
Li, XJ;Kusagawa, S;Takebe, Y
对昆明市11名静脉吸毒者和15名异性恋者进行了分子流行病学调查。根据2.6kb gag-RT区的核苷酸序列确定HIV-1基因型。注射吸毒者基因型分布为：CRF07_BC（5/11）和CRF08_BC（5/11），B'亚型（1/11）。同样，昆明异性恋者中大多数（14/15）感染了CRF07_BC（4/15）、CRF08_BC（6/15）或B'亚型（4/15），已知这些亚型在中国的注射吸毒者中占主导地位。这与中国沿海地区和周边东南亚国家的趋势形成鲜明对比，在这些国家，CRF01_AE在异性恋者中占主导地位。因此，昆明的异性恋HIV-1流行似乎源于当地的IDU流行。值得注意的是，B'亚型在1997年之前是昆明市异性恋人群中最常见的毒株，而CRF07_BC和CRF08_BC亚型在2002年成为主要毒株，表明昆明市异性恋人群中HIV-1基因型分布在早期和晚期之间发生了转变。
Molecular epidemiological investigation was conducted among injecting drug users (IDUs) (n = 11) and heterosexuals (n = 15) in Kunming, Yunnan Province of China. HIV-1 genotypes were determined based on the nucleotide sequences of 2.6-kb gag-RT region. The distribution of genotypes among IDUs was as follows: CRF07_BC (5/11) and CRF08_BC (5/11); subtype B' (1/11). Similarly, a majority of Kunming heterosexuals (14/15) were infected with CRF07_BC (4/15), CRF08_BC (6/15), or subtype B' (4/15), known to predominate among IDUs in China. This contrasts with trends in the coastal regions of China and surrounding southeastern Asian countries, where CRF01_AE predominates among heterosexuals. The heterosexual HIV-1 epidemic in Kunming thus appears to derive from the local IDU epidemic. Of note, subtype B' was the most prevalent strain among heterosexuals before 1997, while CRF07_BC and CRF08_BC became predominant in 2002, indicating a transition of HIV-1 genotype distribution between the early and the more recent samples from Kunming heterosexuals.