Sodium Tanshinone II A Sulfonate Injection as Adjuvant Treatment for Unstable Angina Pectoris: A Meta-Analysis of 17 Randomized Controlled Trials
Sodium Tanshinone II A Sulfonate Injection as Adjuvant Treatment for Unstable Angina Pectoris: A Meta-Analysis of 17 Randomized Controlled Trials
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丹参酮IIA磺酸钠注射液辅助治疗不稳定型心绞痛：17项随机对照试验的荟萃分析
DOI：
10.1007/s11655-017-2424-x
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发表时间：
2018-02-01
影响因子：
2.9
通讯作者：
Zhang Bing
中科院分区：
文献类型：
--
作者：
Tan Di;Wu Jia-rui;Zhang Bing
目的：系统评价丹参酮ⅱA磺酸钠注射液（STS）作为一种辅助治疗不稳定性心绞痛（UAP）的有效性和安全性。方法：检索中国国家知识基础数据库（CNKI）、中国科技期刊VIP数据库（VIP）、万方数据库、中国生物医学文献数据库（CBM）、Web of Science、Cochrane图书馆、Embase、PubMed等数据库自建库至2016年1月的随机对照试验（rct）。采用Cochrane风险评估工具评价随机对照试验的方法学质量。采用Review Manager 5.3软件进行meta分析。结果：共纳入17项rct，共1372例患者。荟萃分析表明,联合使用STS和西药(WM)治疗UAP可以明显改善总有效率(风险率(RR) = 1.31, 95%可信区间(CI) (1.24, 1.39), P < 0.0001),和心电图的总有效率(RR = 1.43, 95%可信区间(1.30,1.56),P < 0.0001),降低CRP的水平(平均差(MD) = -3.06, 95%可信区间(-3.85,-2.27),P < 0.00001),纤维蛋白原(MD = -1.03, 95% CI (-1.16, -0.89), P < 0.00001),全血高剪切粘度[MD=-0.70, 95% CI (-0.92,-0.49), P < 0.00001]。研究组药物不良反应发生率显著高于对照组[RR=3.57, 95% CI (1.28, 9.94), P < 0.05]。结论：与WM相比，STS联合应用更有效。
Objective: To systematically evaluate the effectiveness and safety of Sodium Tanshinone II A Sulfonate Injection (STS) as one adjuvant therapy for treating unstable angina pectoris (UAP). Methods: Randomized controlled trials (RCTs) of UAP treated by STS were searched in the China National Knowledge Infrastructure Database (CNKI), VIP Database for Chinese Technical Periodicals (VIP), Wanfang Database, the Chinese Biomedical Literature Database (CBM), Web of Science, the Cochrane Library, Embase, and PubMed, which from inception to January, 2016. The Cochrane Risk Assessment Tool was used to evaluate the methodological quality of the RCTs. The Review Manager 5.3 software was used to conduct the metaanalysis. Results: The results showed that 17 RCTs involving 1,372 patients were included. The meta-analysis indicated that the combined use of STS and Western medicine (WM) in the treatment of UAP can obviously improve the total effective rate [risk ratio (RR)=1.31, 95% confidence interval (CI) (1.24,1.39), P < 0.0001], and the total effective rate of electrocardiogram [RR=1.43, 95% CI (1.30,1.56), P < 0.0001], decrease the level of CRP [mean difference (MD)=-3.06, 95% CI (-3.85,-2.27), P < 0.00001], fibrinogen [MD=-1.03, 95% CI (-1.16,-0.89), P < 0.00001], and whole blood high shear viscosity [MD=-0.70, 95% CI (-0.92,-0.49), P < 0.00001]. Additionally, the occurrence of adverse drug reaction of the experimental group was significantly higher than that of the control group [RR=3.57, 95% CI (1.28, 9.94), P < 0.05]. Conclusions:Compared with WM, the combined use of STS was more effective.