Increased Noradrenaline Content of Hypothalamic Nuclei in Association with Worsening of Hypertension after High Sodium Intake in the Young Spontaneously Hypertensive Rat
Increased Noradrenaline Content of Hypothalamic Nuclei in Association with Worsening of Hypertension after High Sodium Intake in the Young Spontaneously Hypertensive Rat
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自发性高血压幼鼠高钠摄入后下丘脑核去甲肾上腺素含量增加与高血压恶化相关
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
S. Oparil
中科院分区：
文献类型：
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作者：
S. Winternitz;J. Wyss;J. Meadows;S. Oparil
1. 在冈本品系的年轻自发性高血压大鼠（SHR）中，高钠摄入会导致高血压恶化，并伴有外周交感神经活动增加的证据。 2. 为了验证高钠摄入量通过影响参与心血管调节的中枢去甲肾上腺素能通路来增加外周交感神经活动的假设，在年轻的 SHR 中检查了膳食钠摄入量对个体下丘脑核团去甲肾上腺素储存的影响。 3.高钠摄入2周后，与正常钠摄入的SHR相比，SHR下丘脑前核和背内侧核团的去甲肾上腺素含量增加。下丘脑前核去甲肾上腺素含量的增加持续到第 4 周。其他检查区域没有发现任何变化。 4. 这些观察结果支持了钠和交感神经系统在 SHR 高血压发病机制中具有协同作用的假设。
1. High sodium intake results in an exacerbation of hypertension accompanied by evidence of increased peripheral sympathetic activity in the young spontaneously hypertensive rat (SHR) of the Okamoto strain. 2. To examine the hypothesis that high sodium intake increases peripheral sympathetic activity via an influence on central noradrenergic pathways involved in cardiovascular regulation, the effect of dietary sodium intake on noradrenaline stores of individual hypothalamic nuclei was examined in young SHR. 3. After 2 weeks of high sodium intake, the noradrenaline content of the anterior and dorsomedial hypothalamic nuclei of SHR was increased when compared with SHR receiving normal sodium intake. Increases in the noradrenaline content of anterior hypothalamic nucleus persisted at 4 weeks. No changes were seen in other regions examined. 4. These observations lend support to the hypothesis that sodium and the sympathetic nervous system have synergistic effects in the pathogenesis of hypertension in the SHR.