Palladium-Catalyzed Trifluoroethylation of Terminal Alkynes with 1,1,1-Trifluoro-2-iodoethane
Palladium-Catalyzed Trifluoroethylation of Terminal Alkynes with 1,1,1-Trifluoro-2-iodoethane
复制标题
钯催化末端炔烃与 1,1,1-三氟-2-碘乙烷的三氟乙基化
DOI：
10.1021/ol400099h
复制
发表时间：
2013-02-15
期刊：
影响因子：
5.2
通讯作者：
Xu, Hua-Jian
中科院分区：
文献类型：
--
作者：
Feng, Yi-Si;Xie, Chuan-Qi;Xu, Hua-Jian
采用pd催化的2,2,2-三氟乙基化方法制备了一种高效的C-sp-CH2CF3成键反应。本方案在温和条件下进行，使用易于获得和廉价的试剂CF3CH2I作为CH2CF3基团的来源。各种末端芳炔和烷基乙炔可以转化为相应的三氟乙基化产品，收率很高。该方法对羰基、硝基、酯、氰基、甚至甲酰都有耐受性。
An efficient C-sp-CH2CF3 bond-forming reaction via Pd-catalyzed 2,2,2-trifluoroethylation of aryl and alkyl terminal alkynes has been developed. This protocol proceeds under mild conditions using the readily available and cheap reagent CF3CH2I as the source of the CH2CF3 group. Various terminal aryl alkynes as well as alkylacetylenes can be transformed Into the corresponding trifluoroethylated products In good-to-excellent yields. The method is tolerant of carbonyl, nitro, ester, cyano, and even formyl groups.