CHRONIC NEUROENDOCRINOLOGICAL SEQUELAE OF RADIATION-THERAPY
CHRONIC NEUROENDOCRINOLOGICAL SEQUELAE OF RADIATION-THERAPY
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DOI：
10.1016/0360-3016(94)00427-m
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发表时间：
1995-03-30
影响因子：
7
通讯作者：
CONSTINE, LS
中科院分区：
文献类型：
--
作者：
SKLAR, CA;CONSTINE, LS
当下丘脑-垂体轴（HPA）包括在治疗范围内时，观察到各种神经内分泌紊乱。辐射引起的异常通常是剂量依赖性的，可能在照射多年后发生。生长激素缺乏和性发育过早可在低至18戈瑞的分割辐射剂量下发生，并且是儿童中最常见的神经内分泌问题。促性腺激素、促甲状腺激素和促肾上腺皮质激素缺乏主要见于接受bbb40戈瑞HPA辐射治疗的个体。高剂量放疗后可出现高催乳素血症，特别是在年轻女性中。大多数由高剂量放射治疗引起的神经内分泌紊乱是可以治疗的；有风险的患者需要长期的内分泌随访。
A variety of neuroendocrine disturbances are observed following treatment with external radiation therapy when the hypothalamic-pituitary axis (HPA) is included in the treatment field. Radiation-induced abnormalities are generally dose dependent and may develop many years after irradiation. Growth hormone deficiency and premature sexual development can occur following doses as low as 18 Gy fractionated radiation and are the most common neuroendocrine problems noted in children, Deficiency of gonadotropins, thyroid stimulating hormone, and adrenocorticotropin are seen primarily in individuals treated with > 40 Gy HPA irradiation. Hyperprolactinemia can be seen following high-dose radiotherapy (> 40 Gy), especially among, young women, Most neuroendocrine disturbances that develop as a result of HPA irradiation are treatable; patients at risk require long-term endocrine follow-up.