Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease.
Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease.
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DOI：
10.1016/j.freeradbiomed.2010.04.004
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发表时间：
2010-08-01
影响因子：
7.4
通讯作者：
Giulivi, Cecilia
中科院分区：
文献类型：
--
作者：
Villanueva, Cleva;Giulivi, Cecilia
关键词：
一氧化氮在生物系统中的作用取决于它的稳态浓度和产生的地点。产生一氧化氮的器官是相关的，在器官中，哪些类型的细胞实际上对这种产生起到了作用，似乎是其效果的主要决定因素。特定一氧化氮合酶的亚细胞区隔作用已被证明在健康和疾病中发挥重要作用。病理生理条件影响一氧化氮合酶的细胞表达和定位，进而改变器官的串扰。在这项研究中，我们描述了一氧化氮在器官、细胞和亚细胞细胞器中的区划，以及它的定位如何与几个相关的临床情况有关。了解一氧化氮产生区隔的复杂性以及这种区隔在细胞靶标和下游影响方面的影响，最终将有助于制定更好的战略，以治疗或预防与一氧化氮产生的增加、抑制或错误定位相关的病理事件。
The effects of nitric oxide in biological systems depend on its steady-state concentration and where it is being produced. The organ where nitric oxide is produced is relevant, and within the organ, which types of cells are actually contributing to this production seem to play a major determinant of its effect. Subcellular compartmentalization of specific nitric-oxide synthase enzymes has been shown to play a major role in health and disease. Pathophysiological conditions affect the cellular expression and localization of nitric oxide synthases, which in turn alter organ cross talk. In this study, we described the compartmentalization of nitric oxide in organs, cells and subcellular organelles, and how its localization relates to several relevant clinical conditions. Understanding the complexity of the compartmentalization of nitric oxide production and the implications of this compartmentalization in terms of cellular targets and downstream effects will eventually contribute toward the development of better strategies for treating or preventing pathological events associated with the increase, inhibition or mislocalization of nitric oxide production.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1152/ajpheart.1995.268.3.h1106
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