Neurocognitive impairment and psychiatric comorbidity in well-controlled human immunodeficiency virus-infected Thais from the 2NN Cohort Study
Neurocognitive impairment and psychiatric comorbidity in well-controlled human immunodeficiency virus-infected Thais from the 2NN Cohort Study
复制标题
DOI：
10.3109/13550280903493914
复制
发表时间：
2010-02-01
影响因子：
3.2
通讯作者：
Valcour, Victor
中科院分区：
文献类型：
--
作者：
Pumpradit, Wadchara;Ananworanich, Jintanat;Valcour, Victor
这项研究是一项横断面研究，旨在确定在2NN队列中使用不可检测的血浆人类免疫缺陷病毒(HIV)RNA的泰国人中，接受高效抗逆转录病毒治疗(HAART)的泰国人中神经认知障碍和精神共病的频率。对64名受试者进行了神经学检查、神经心理测试和精神病学问卷调查。有神经认知障碍者24例(37.5%)，其中无症状神经认知障碍(ANI)13例(20.3%)，轻度神经认知障碍(MND)10例(15.6%)，HIV相关性痴呆(HAD)1例(1.6%)。3名受试者(4.7%)有抑郁，没有病例有明显的焦虑症状。在控制良好的个体中，有相当比例的人出现了神经认知障碍。焦虑和抑郁并不常见。
This research is a cross-sectional study to determine the frequency of neurocognitive impairment and psychiatric comorbidity among Thais maintained on highly active antiretroviral therapy (HAART) with undetectable plasma human immunodeficiency virus (HIV) RNA in the 2NN Cohort. Sixty-four subjects were evaluated with neurological examinations, neuropsychological testing, and psychiatric questionnaires. Twenty-four subjects (37.5%) were found to have neurocognitive impairment, with 13 (20.3%), 10 (15.6%), and 1 (1.6%) classified as asymptomatic neurocognitive disorder (ANI), mild neurocognitive disorder (MND), and HIV-associated dementia (HAD), respectively. Three subjects (4.7%) had depression and no cases had significant symptoms of anxiety. A notable proportion of well-controlled individuals exhibited neurocognitive impairment. Anxiety and depression were uncommon.