A role for the subthalamic nucleus in response inhibition during conflict.
A role for the subthalamic nucleus in response inhibition during conflict.
复制标题
DOI：
10.1523/jneurosci.2259-12.2012
复制
发表时间：
2012-09-26
期刊：
影响因子：
--
通讯作者：
Jenkinson N
中科院分区：
文献类型：
--
作者：
Brittain JS;Watkins KE;Joundi RA;Ray NJ;Holland P;Green AL;Aziz TZ;Jenkinson N
丘脑底核（subthalamic nucleus，简称丘脑底核）是支持反应抑制的网络中的关键节点。这表明，在冲突期间，大脑皮层迅速抑制基底神经节活动，暂停运动输出，直到准备好适当的运动计划。在这里，我们通过植入人类大脑的脑深部刺激电极记录了Stroop任务期间的神经活动。我们的目的是确定是否认知心理现象，如Stroop效应可以解释通过机制的反应抑制，涉及的神经元，或者如果更高的认知中心单独负责。我们显示了在整个言语反应中持续的β波段（15 - 35 Hz）中的刺激驱动的去同步化，这与β波段同步性降低以允许运动输出发生的想法一致。在不一致的试验中，由于Stroop效应，反应时间延长，在反应前的β带中观察到了一个突变。至关重要的是，在不一致的试验中，受试者无法抑制预效反应，这种抑制发生在反应发生后。我们认为，这种β-波段的同步化暂停了运动系统，直到冲突得到解决。
The subthalamic nucleus (STN) is a key node in the network that supports response inhibition. It is suggested that the STN rapidly inhibits basal ganglia activity, to pause motor output during conflict until an appropriate motor plan is ready. Here, we recorded neural activity during a Stroop task from deep brain stimulation electrodes implanted in the human STN. We intended to determine whether cognitive psychological phenomena such as the Stroop effect can be explained via mechanisms of response inhibition involving the STN, or if higher cognitive centres are alone responsible. We show stimulus driven desychronisation in the beta-band (15 – 35 Hz) that lasts throughout the verbal response, in keeping with the idea that beta-band synchrony decreases to allow motor output to occur. During incongruent trials - where response times were elongated due to the Stroop effect - a resynchronisation was seen in the beta-band prior to response. Crucially, in the incongruent trials during which the participant was unable to withhold the pre-potent response this resynchronisation occurred after response onset. We suggest that this beta-band resynchronisation pauses the motor system until conflict can be resolved.