Effect of endogenous sulfur dioxide in regulating cardiovascular oxidative stress.
Effect of endogenous sulfur dioxide in regulating cardiovascular oxidative stress.
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DOI：
10.14670/hh-29.1107
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发表时间：
2014-04
影响因子：
2
通讯作者：
Mingzhu Zhu;Junbao Du;Angie Dong Liu;Lukas Holmberg;Chao-shu Tang;Hongfang Jin
中科院分区：
文献类型：
--
作者：
Mingzhu Zhu;Junbao Du;Angie Dong Liu;Lukas Holmberg;Chao-shu Tang;Hongfang Jin
20世纪80年代中期，一氧化氮因其在生命科学中的重要作用而受到广泛关注。随后，一氧化碳和硫化氢被发现是在调节细胞内稳态中起重要作用的气体递质。作为一种常见的空气污染物，二氧化硫（SO_2）会通过产生自由基对人体造成极大的危害，对各种器官造成氧化损伤。近年来，研究发现内源性SO2在心血管系统中产生，可能是一种调节心血管氧化应激等生理活动的生物活性分子。
In the middle of the 1980s, nitric oxide received extensive attention because of its significant effects in life science. Then, carbon monoxide and hydrogen sulfide were discovered to be gasotransmitters playing important roles in regulating cellular homeostasis. As a common air pollutant, sulfur dioxide (SO₂) can cause great harm to the human body by producing free radicals, which causes oxidative damage to various organs. Recently, endogenous SO2 was found to be produced in the cardiovascular system and might be a bioactive molecule regulating the physiological activities including cardiovascular oxidative stress.